生长抑素联合加贝酯治疗重型急性胰腺炎

Therapeutic effect on acute necrotizing pancreatitis of gabexate mesilate combining with somatostatin

目的观察生长抑素联合加贝酯治疗重型急性胰腺炎的疗效。方法选取我院重型急性胰腺炎患者53例,分为单用生长抑素组、生长抑素联合加贝酯组、生长抑素联合乌司他丁组。观察血清淀粉酶、白细胞、血糖、血钙恢复时间及腹痛、上腹部压痛缓解时间的指标差异。结果生长抑素联合加贝酯组、生长抑素联合乌司他丁组以上指标恢复时间均短于单用生长抑素组,P<0.05。生长抑素联合加贝酯组白细胞恢复时间短于生长抑素联合乌司他丁组(P<0.05),而其他指标两组比较差异无统计学意义(P>0.05)。结论应用生长抑素联合加贝酯、生长抑素联合乌司他丁治疗重型急性胰腺炎较单独应用生长抑素效果好。生长抑素联合加贝酯组白细胞恢复时间较生长抑素联合乌司他丁组短,而两组在血清淀粉酶、血糖、血钙恢复时间及腹痛、上腹部压痛缓解时间的指标上无明显差异。

Objective To compare the therapeutic effect on severe acute pancreatitis by somatostain alone, gabexate mesilate combining with somatostatin and ulinastatin combining with somatostatin. Methods Fifty-three pa- tients with severe acute pancreatitis were enrolled. Treatment group I received intravenous gabexate mesilate combi- ning with somatostatin, and treatment group Ⅱ received ulinastatin combining with somatostatin, the control group re- ceived intravenous somatostain alone. The recovery time of serum amylase, WBC, blood glucose, blood calcium, ab- dominal pain and abdominal tenderness were observed. Results The targets above of group I and group Ⅱ was much shorter than that of the control group,P 〈0.05. The recovery time of WBC of group I was shorter than that of group Ⅱ , P 〈 0. 05, but the recovery time of serum amylase, blood glucose, blood calcium, abdominal pain and abdominal tendemess of group I and group Ⅱ had no distinct difference, P 〉 0. 05. Conclusion Intravenous gabexate mesilate com- bining with somatostatin infusion, intravenous ulinastatin combining with somatostatin is more effective than intravenous somatostatin infusion alone. The recovery time of WBC of intravenous gabexate mesilate combining with somatostatin infusion is shorter than that of intravenous ulinastatin combining with somatostatin, e 〈 0. 05, but the recovery time of serum amylase, blood glucose, blood calcium, abdominal pain and abdominal tenderness of the two group have no dis- tinct difference.