贝那普利治疗糖尿病肾病临床分析

Clinical analyze of Benazepril to treat diabetic nephrosis

目的:探讨贝那普利治疗糖尿病肾病的临床效果。方法:选择2008年7月～2009年5月在四川省崇州市人民医院住院治疗的64例糖尿病肾病患者,随机分为观察组和对照组,每组32例,对照组单用氯沙坦治疗,观察组在此基础上加用贝那普利,比较两组疗效。结果:观察组显效率为62.5%,有效率为21.9%,治疗总有效率为84.4%,对照组显效率、有效率和总有效率分别为34.4%、21.9%和56.3%,两组比较差异有统计学意义(P<0.05),观察组治疗效果要优于对照组;两组患者治疗前的各项检查指标相比,差异无统计学意义,两组治疗后24h蛋白尿(UAE)、血肌酐(Cr)和尿素氮(BUN)的浓度与治疗前比较,均显著下降,差异有统计学意义(P<0.05),但观察组下降幅度更大,治疗后与对照组相比,差异有统计学意义(P<0.05)。结论:贝那普利可延缓糖尿病肾病的发生和发展,疗效确切且无明显不良反应,值得在临床推广应用。

Objective： To explore the clinical effect of Benazepril to treat diabetic nephrosis. Methods： Selected 64 patients that treated in Chongzhou people＇s hospital from July 2008 to May 2009 and divided into observation group and control group, the control group were treated with losartan only, and the observation group were treated with losartan and Benazepril, compare their treat effect. Results： the marked effect rate of the observation group was 62.5%, the effect rate was 21.9%, the total effect rate was 84.4%, the marked effect rate, effect rate and total effect rate of the control group was 34.4%, 21.9% and 56.3%, the difference was statistical significant（P〈0.05）; there were no different of the indexes in the two groups before treat, but the indexes of UAE, Cr and BUN were obviously reduced after treated, but the observation reduced more obviously than the control group, the difference had statistical significant （P〈0.05）. Conclusion： Benazepril is effect to treat diabetic nephrosis and can be widely used in clinic.