宫颈细胞TBS+DNA倍体定量检测在宫颈病变中的应用

The purpose of cervical cells by TBS + DNA quantitative detection in cervical lesions

目的:通过对宫颈细胞TBS+DNA倍体定量检测,及早发现宫颈病变,阻断宫颈癌的发生。方法:对妇科门诊就诊的1000例妇女进行宫颈细胞TBS+DNA倍体定量检测,阳性患者再做宫颈活检。诊断标准采用TBS分类系统。结果:1000例妇女宫颈刮片标本,TBS+DNA倍体定量检测阳性53例,阳性率为5.3%,其中不典型腺细胞(AGCUS)2例,低度鳞状上皮内病变(LSIL)40例,高度鳞状上皮内病变(HSIL)9例,鳞状细胞癌(SCC)2例。53例阳性者进行宫颈活检,其中轻度不典型腺上皮增生2例,CINⅠ39例,CINⅡ7例,CINⅢ3例,SCC2例。宫颈活检对TBS+DNA倍体检测提供的阳性病变加以确诊。30～40岁年龄阶段是CIN的高发年龄,发病率为56.6%(30/53)。结论:宫颈细胞TBS+DNA倍体定量测定与病理组织学有一定的相关性。TBS+DNA倍体定量测定作为无创伤检测是门诊筛查子宫颈癌的有效方法。对年轻妇女应特别关注宫颈癌的门诊筛查工作。

Objective： The purpose of cervical ceils by TBS ＋ DNA ploidy quantitative detection, early detection of cervical lesions, blocked the occurrence of cervical cancer. Methods： Gynecology clinics of 1 000 cases of cervical cells, women in TBS ＋ DNA ploidy quantitative tests in patients with positive cervical biopsy done. Diagnostic criteria for the use of TBS classification systems. Results： 1 000 cases of women in cervical scrape specimens films, TBS ＋ DNA ploidy in 53 cases of positive quantitative detection, the positive rate was 5.3%, in which atypical glandular cells （AGCUS） 2 cases, low-grade squamous intraepithelial lesion （LSIL） 40 cases, a high degree of squamous intraepithelial lesion （HSIL） 9 cases of squamous cell carcinoma （SCC） 2 cases. Positive for 53 cases of cervical biopsy, which mild atypical glandular hyperplasia and 2 cases, CIN Ⅰ 39 cases, CIN Ⅱ 7 cases, CIN Ⅲ 3 cases, SCC 2 cases. Cervical biopsy of TBS ＋ DNA ploidy provide positive detection of lesions to be diagnosed. Ages 30-40 years of age is the age of high incidence of CIN, the probability was 30/53 （56.6%）. Conclusion：Cervical cells TBS＋DNA ploidy and quantitative determination of some histological correlation. TBS＋DNA quantitative determination of ploidy as a non-invasive detection of out-patient screening is an effective method for cervical cancer. Screening for cervical cancer patient to pay special attention to young women.