重型颅脑损伤早期加强营养支持的临床研究

Study on early nutritional support for the severe brain injury patients

目的探讨重型颅脑损伤早期加强营养支持的临床意义及对预后的影响。方法选择重型颅脑损伤患者56例，随机分为治疗组28例和对照组28例。治疗组采用早期肠内外复合营养加强治疗，对照组常规治疗。观察治疗后患者的淋巴细胞计数、免疫球蛋白浓度、血红蛋白、血清白蛋白、转铁蛋白、前白蛋白、并发症发生率及预后。结果治疗组病例营养状态明显好于对照组（P〈0．05），预后差异有统计学意义。结论重型颅脑损伤患者早期加强营养支持有利于颅脑损伤患者病情恢复及改善预后。

Objective To investigate the prognosis and clinical significance of early nutritional support in the patients with severe brain injury. Methods 56 patients with severe brain injury were randomly divided into therapy group and control group. The patients of therapy group were fed on both parenteral and enteral nutrition in the early period, and the patients of control group were nutritionally supported with common method. The patients＇ lymphocyte count, concentrations of immune globulin, hemoglobin, serum albumin, transferrin, prealbumin, the incidences of complications and prognosis were observed. Results The nutrition conditions of the therapy group were better than that of the control group （ P 〈 0.05 ）. There was significant difference in prognosis. Conclusion Early nutritional support of the patients with severe brain injury would be beneficial to their rehabilitation, and can change the patients＇ prognosis.