正电子放射性药物的点击合成

Click synthesis of PET radiopharmaceuticals

正电子放射性药物的合成是核技术应用领域的焦点之一。近年来点击化学因其高速、高收率、高选择性和条件温和等优点而应用于正电子放射性药物的合成。本文综述了近年来点击化学在PET药物合成中的研究进展(包括将18F和11C导入药物分子),并展望其发展前景。

Increasing attention has been focused on synthesis radiopharmaceuticals for positron emission tomography （PET）. The recent years witnessed applications of click chemistry to PET radiopharmaceutical synthesis, because of its distinctive advantages including high speed, yield and stereospecificity under mild conditions. Synthesis of ^18F-labeled and ^11C-labeled radiopharmaceuticals and intermediates via click chemistry are reviewed. The future trend of click chemistry for the synthesis of PET radiopharmaceutical is prospected.