多发性骨髓瘤存活期及影响因素研究

The survival time and correlation factors of patients with multiple myeloma.

目的探讨多发性骨髓瘤(MM)患者长期存活的相关因素。方法统计天津医科大学总医院1983年1月至2007年9月MM患者存活期并分析其影响因素。结果107例MM患者中位存活32个月。单因素分析显示发病年龄、髓外浸润、合并感染、外周血血小板计数、血清白蛋白、β2-微球蛋白、尿酸、骨髓浆细胞比例及形态、治疗后是否达到骨髓细胞形态学完全缓解(CR)是本组MM患者存活期的影响因素。多因素分析显示外周血血小板计数、血清β2-微球蛋白、骨髓细胞分类中浆细胞类型和治疗后是否达到骨髓细胞形态学CR是MM患者存活期的独立影响因素。结论近20余年,MM患者中位存活近3年,其外周血血小板计数、血清β2-微球蛋白、骨髓浆细胞类型和治疗后达否骨髓细胞形态学CR是影响存活期的独立因素。

Objective To investigate the survival time and the correlation factors of patients with Multiple Myeloma （MM）. Methods The survival time of 107 MM patients hospitalized in the General Hospital of Tianjin Medical University between January 1983 and September 2007 and its influencing factors were retrospectively analyzed. Results The median survival time of the 107 MM patients was 32 months. Mono-factor analysis suggested that factors-such as the age of onset, the extra-marrow infiltration, the concurrent infection, the platelet count, the serum level of albumin and β2-microglobulin, the serum uric acid, the percentage and morphous of plasma cells in bone marrow, and whether reaching to mor- phological complete remission （CR） after treatment-were influencing indexes for the survival time of MM patients. Multi- plicity indicated that the platelet count of peripheral blood, the serum level of β2-microglobulin, the type of plasma cells in bone marrow differentiation and whether reaching to morphological CR after treatment were independent factors for the MM patients＇ survival time. Conclusion In the recent 20 more years, the median survival time for MM patients was 3 years, and the platelet count, the serum level of β2-mieroglobulin, the type of plasma cell and whether reaching to morphological CR after treatment were independent factors for the MM patients＇ survival time.