杏丁注射液联合速效救心丸对急性冠状动脉综合征患者血管内皮功能及因子的影响

Influence of Xingding Injection Combined with Suxiaojiuxin Pill on Function and Factors in Endothelium of Acute Coronary Syndrome Patients

目的观察杏丁注射液联合速效救心丸对急性冠状动脉综合征(ACS)患者血管内皮功能和血管内皮因子的影响。方法将ACS患者96例随机分为治疗组(杏丁注射液+速效救心丸)与对照组(杏丁注射液);治疗前及治疗2个疗程后测定患者血管内皮功能和血管内皮因子含量。结果与治疗前比较,两组治疗后D0、D1的直径和△D均表现为增加,除D0的直径外,D1和△D均有显著性差异。组间比较,D1和△D有显著性差异。治疗后NO含量分别增加68.15%、32.62%;而ET-1含量分别降低50.69%、25.88%。组间比较内皮因子含量变化有显著性差异。结论杏丁注射液与速效救心丸联用可显著改善血管内皮依赖性舒张功能,改变血管内皮因子的浓度。

Objective： To observe influence of Xingding Injection combined with Suxiaojiuxin Pill on function and factors in endothelium of acute coronary syndrome（ACS） patients. Methods： 96 ACS patients were randomly divided into treatment group （ Xingding Injection combined with Suxiaojiuxin Pill） and control group （ Xingding Injection）. The function and the factors in endothelium of patients were detected before and after two treatment courses. Results： After treatment, the diameters of D0, D1 and A D were increased in two groups. The D1 and △D had a significant difference except to Do. Compared to the control group, there was a statistical difference in D1 and △D between two groups. Moreover, the content of NO respectively increased 68. 15% and 32.62% after treatment, but the level of ET - 1 respectively decreased 50. 69% and 25.88%. Besides that, the contents of endothelium were remarkable differences between two groups. Conclusion： Xingding Injection combined with Suxiaojiuxin Pill could significantly increased the diastolic function and the concentration of endotbelium in ACS patients.