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填髓益脑法对大鼠脑缺血再灌注增殖细胞核抗原表达的实验研究 被引量：3

The Effect of Tiansuiyinao Decoction on PCNA Expression of Cerebral Ischemic Reperfusion in Rats
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摘要 目的探讨填髓益脑法对脑缺血再灌注神经干细胞(NSC)内源性激活的作用。方法采用线栓法建立大鼠大脑中动脉阻塞(MCAO)模型,采用链菌素亲生物素-过氧化物酶连接法(SP法)测定增殖细胞核抗原(PCNA)的表达。结果填髓益脑法对缺血性大鼠PCNA表达明显高于对照组。结论填髓益脑法在脑缺血再灌注实验中可以促进脑缺血再灌注NSC的增殖。 Objective： To investigate the neural stem cell endogenous activation effects of the Tiansuiyinao Decoction on cerebral ischemia reperfusion in rats. Methods： The MCAO model was established and the expression of the PCNA was determined by the sp law. Results： The expression of the PCNA was higher significantly in Tiansuiyinao Decoction group than that in control group. Conclusion： The Tiansuiyinao Decoction can promote the neural stem cell multiplication in cerebral ischemia reperfusion in rats.
作者 丁念 张觉人
机构地区 湖北省武汉市中医医院
出处 《中国中医急症》 2009年第8期1301-1302,1314,共3页 Journal of Emergency in Traditional Chinese Medicine
关键词 脑缺血再灌注 填髓益脑法 增殖细胞核抗原 大鼠 Cerebral ischemia reperfusion PCNA Rats Tiansuiyinao Decoction
分类号 R285.5 [医药卫生—中药学]
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参考文献15

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中国中医急症
2009年 第8期

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