头孢泊肟酯侧链的合成研究——1-氯乙基异丙基碳酸酯的制备

Synthesis of the Side Chain of Cefpodoxime Proxetil——The Preparation of 1Chloroethyl Isopropyl Carbonate

通过氯化、酯化反应合成了β内酰胺类抗生素———头孢泊肟酯４位侧链１氯乙基异丙基碳酸酯，产品纯度达９０％，收率为５０％，接近文献值，工艺简单，适于工业化生产．

As an intermediate at the 4th position of the side chain of Cefpodoxime Proxetil,1chloroethyl isopropyl carbonate was synthesized by two steps: chlorination and esterification.The yield was 50%,and the purity was up to 90%which has never been reported.The process may be easily used in industry.