Schiff碱型γ-氨基丁酸衍生物的合成

Synthesis of Schiff Bases of γ Aminobutyric Acid

生理条件下γ氨基丁酸不易透过血脑屏障进入脑组织。为了增大γ氨基丁酸的脂溶性，使其能透过血脑屏障进入脑组织，通过亚胺键将γ氨基丁酸接到一个亲脂性载体上，设计并合成了７个４［（４氯苯基）（５氟２羟基苯基）亚甲氨基］丁酸酯，３个４（３甲氧基４羟基苯亚甲氨基）丁酸酯和６个４（２，４二羟基苯亚甲氨基）丁酸酯三个类型共１６个γ氨基丁酸衍生物，样品经元素分析、红外光谱、质谱和核磁共振氢谱检测与目标化合物一致。采用三氟化硼乙醚作催化剂合成Ｓｃｈｉｆ碱。

The authors have designed and synthesized 16 derivatives of γ aminobutyic acid with an imine link to a lipophilic carrier in order to facilitate the passage of γ aminobutyric acid across the blood brain barrier. The synthesized compounds were identified with elementary analysis, IR, MS and 1 HNMR.It shows that the results are consistent with chemical structure.