调节胆固醇代谢的新药物靶点LXR

New Drug Targets LXR for Cholesterol Control

本文对细胞核受体LXRs(Liver X Receptors)及其天然和人工合成配体的发现进行了系统简介,着重描述了部分激动剂的药理作用,及其作为胆固醇代谢调节因子在疾病动物模型上的初步验证。LXR选择性激动剂可以对动脉粥样硬化和老年痴呆症的延缓及预防起积极作用,有潜力成为临床治疗药品。

This brief review summarizes the discovery and development of nuclear receptor LXRs （Liver X Receptors） and their naturally occurring or synthetic ligands, with an emphasis on the pharmacological effects of some agonists, especially their therapeutic value on model animals as cholesterol metabolism regulators. It seems plausible for LXR selective modulators to be developed into clinical agents against vascular atherosclerosis and Alzheimer＇s disease.