泮托拉唑治疗老年急性上消化道出血的临床观察

Observe the therapeutic eft cacies of the acute upper gastrointestinal tract heam orrhage with pantoprazole

目的观察泮托拉唑治疗老年急性上消化道出血的临床疗效和安全性。方法168例大于60岁以上急性上消化道出血患者，用泮托拉唑针剂40mg静滴bid，对照组用奥美拉唑针剂40mg静注bid治疗对比，观察两组的止血时间、心、肝、肾功能生化指标。结果泮托拉唑组和奥美拉唑组的治疗总有效率分别为98．73％和71．82％，两组比较有显著性差异（P〈0．05）。呕血、黑便停止时间两组无显著差异（P〉0．05）。两组生化指标均无异常改变，均无明显不良反应。结论泮托拉唑治疗老年急性上消化道出血疗效显著，无明显毒副作用。

Objective To observe the therapeutic efficacies of the acute upper gastrointestinal tract heamorrhage with pantoprazole. Methods 98 patiens diagnosed acute upper gastrointestinal tract heamorrhage by endoscopy were allocated randomly into three groups：group A. B and C. Group A 36 cases were treated with pantoprazole 40 mg VD bid ; Group B 33 cases were treated with famotidine 20 mg VD bid ; Group C 29 cases were treated with acidi aminomethylbenzoici 300 mg VD bid. The course of therapy was 48 hours. The status of clinical symptoms an d side effects were observed and recorded in the period of treatments. Results Th e efective rate in group A,B and C were 97.22,78. 79% and 55.17 respectively The differences were significant statistically between group A and C and between group B and C （ P 〈 0. O1 ）. Conclusion The pantoprazole seems to be best drug in the therapeutic efects of the acute upper gastrointestinal tract heamorrhage and the side effect is less.