口服大黄煎剂治疗急性重症胰腺炎的临床研究

Clinical Study of Oral Rhubarb decoction on the Patients With Severe Acute Pancreatitis

目的观察口服大黄煎剂对急性重症胰腺炎患者的疗效影响。方法72例急性重症胰腺炎患者随机分为治疗组和对照组：对照组（37例）应用常规治疗；治疗组（35例）在常规治疗基础上，口服大黄煎剂治疗。以WBC、BAMS、UAMS、LPS、IL-6等作为指标，观察两种不同方法治疗后的变化。结果治疗组在72h后，临床疗效和血中各指标水平明显优于对照组（P〈0．01）。结论口服大黄煎剂可明显降低急性重症胰腺炎患者血中WBC、BAMS、UAMS、LPS、IL-6水平，辅助应用大黄治疗急性重症胰腺炎较单纯常规治疗的疗效好。

Objective To determine the elinical effeetions and to observe the level changes of WBC, BAMS,UAMS,LPS,IL-6 in plasma of the patients with the severe acute pancreatitis of Rhubarb decoction. Methods 72 eases with severe acute pancreatitis were randomly divided into control group （37 eases） treated by using conventional therapy and treatment group （35 eases） treated by Rhubarb decoction besides the conventional therapy. The level change of plasma WBC,BAMS,UAMS,LPS,IL-6 and the clinical effeetions as index were observed after executing two kinds of treatment strategy. Results The clinical result and the level of these index after employing Rhubarb decoction was gradually dropped and the degree of lower level was remarkable significance（ P 〈 0. 01 ）, compared with control group. Conclusion Rhubarb decoction was effective and obviously reduced level of plasma WBC ,BAMS,UAMS,LPS、IL-6 in the patients with the severe acute pancreatitis.