摘要
本文采用新型高效的碱式碳酸铜－ＤＭＦ催化体系，并以廉价甲醇代替ＤＭＦ为溶剂，系统地考察了由３－溴－４－羟基苯甲醛经甲氧基化反应合成香兰素的反应条件，其中在新型反应体系中，３－溴－４－羟基苯甲醛在１３０℃下于２．６７ｍｏｌ／ｌ的甲醇钠的甲醇溶液中搅拌反应２ｈ，其转化率可达９６．７％。
Abstract By the complete study of methoxylation reaction in the process of synthesizing vanillin from 3-bromo-4-hydroxybenzaldehyde,the reaction condition was improved,which included a mild and efficient cupric subcarbonate-DMF catalytic system was found and the DMF solvent was replaced by methanol.At last,with the cupric subcarbonate DMF system being used as catalyst and methanol as solvent,96.7% 3-bromo-4-hydroxybenzaldehyde could be converted to vanillin at 130℃ for 2h.
出处
《化学工程师》
CAS
1998年第4期14-15,共2页
Chemical Engineer
