我院下呼吸道感染革兰阴性杆菌耐药性检测与抗菌药物应用分析

Detection of Drug Resistance of Gram Negative Bacilli in Patients with Lower Respiratory Infection and Application of Antibacterials

目的:了解我院呼吸科病房下呼吸道感染革兰阴性杆菌的耐药性与抗菌药物应用情况。方法:采用K-B纸片琼脂扩散法进行常规药敏试验,并结合抗菌药物用药频度和销售金额进行分析。结果:铜绿假单胞菌居我院呼吸科病房下呼吸道感染革兰阴性杆菌首位,占22.1%,对美罗培南等抗菌药物较敏感;大肠埃希菌和克雷伯菌属居第2、3位,分别占20.7%和15.1%。在治疗下呼吸道感染革兰阴性杆菌时用药频度较高的是喹诺酮类和第3代头孢菌素类。结论:医院应加强对下呼吸道感染革兰阴性杆菌的耐药监测和抗菌药物应用分析,指导医师合理应用抗菌药物。

OBJECTIVE： To probe into the drug resistance of gram negative bacilli in patients with lower respiratory infection and to analyze the application of antibacterials in the department of respiratory disease. METHODS： Routine drug susceptibility test was conducted by K - B disk agar diffusion method, and the DDDs and consumption sum of the antibacterials were analyzed as well. RESULTS： Pseudomonas aeruginosa which was susceptible to Meropenem took the lead with 22.1% among all the gram negative bacilli in patients with lower respiratory infection, followed by E. coli （20.7%） and Klebsiella （15.1%） . Quinolone and third generation cephalosporins took the lead on the DDDs list in the treatment of gram negative bacilli in patients with lower respiratory infection. CONCLUSION： Hospital should intensify the monitoring of gram negative bacilli in patients with lower respiratory infection and analyzing of the application of antibacterials so as to guide clinicians for a rational use of antibacterials.