胃癌血清E-钙黏附素表达及临床意义

Expression and Clinical Significance of Serum Soluble Epithelial Cadherin in Patients with Gastric Cancer

目的:探讨胃癌患者血清中可溶性E-钙黏附素(sE-Cd)的水平与胃癌侵袭性及复发的关系。方法:用酶联免疫吸附试验(ELISA)测定20名正常人、20例胃癌术后复发患者以及80例胃癌患者术前和术后7、14d的sE-Cd水平,发现其规律,分析sE-Cd水平与胃癌的病理、临床的关系,同时检测血清癌胚抗原(CEA)和糖类抗原19-9(CA19-9)。结果:胃癌及术后复发的患者血清中sE-Cd比正常对照组明显增高,差异有统计学意义(P<0.001);术前、术后血清中sE-Cd浓度比较差异有统计学意义(P<0.001),术后血清sE-Cd浓度下降,与CEA、CA19-9较为一致。结论:sE-Cd在胃癌患者术后和复发患者血清有较高的表达,其浓度对诊断、判定手术预后和及时发现肿瘤的复发等有一定指导意义。

OBJECTIVE： To study the correlation between serum soluble epithelial cadherin （sE - Cd） of patients with gastric carcinoma （GA） and the invasion and recurrence of gastric cancer. METHODS： Concentrations of soluble E- cadherin in 20 healthy adults, 20 recurrent cases after GA surgery and 80 GA cases at 0, 7 and 14 days after operation were determined by enzyme linked immunosorbent assay so as to explore the regular pattern; the correlation between sE - Cd level and the pathology and clinical features of GA was analyzed, and the carcinoembryonic antigen （CEA） and CA19- 9 which served as controls were detected. RESULTS： Serum concentrations of sE- Cd were higher in the patients with postoperative relapse of gastric carcinoma than in normal control（P 〈 0.001） . There were also significant differences in sE- Cd concentration in patients after operation as compared with before operation（P〈 0.001）. The decrease of sE-Cd level was nearly consistent with CEA and CA19 - 9. CONCLUSION ： Serum sE - Cd had high expression in postoperative GA patients, and the concentration of sE - Cd is of significance for the diagnosis and assessment of the postoperative prognosis and timely detection of tumor recurrence etc.