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Gadd45与基因组稳定性

Gadd45 and genomic stability
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摘要 Gadd45基因是生长抑制及DNA损伤诱导基因家族中的一员，是电离辐射效应基因之一，在细胞周期调控、DNA损伤修复及细胞凋亡过程中发挥重要作用，这使它成为维持基因组稳定性的重要基因，在肿瘤细胞存活、凋亡信号通路中发挥错综复杂的作用，从而参与肿瘤的发生和发展。 Gadd45 gene is one of growth arrest and DNA damage-inducible （Gadd） family. It＇s also a gene induced by ionization radiation. It plays an important role in controlling cell cycle, repairing damaged DNA and in cell apoptosis. This makes it work as an improtant gene in mainteining genomic stability, but more importantly it induces eell apoptosis and is a bridge in the cascade process of apoptosis of tumor cell. At the same time, it takes part in tumorigenesis.
作者 贾立立 樊飞跃
机构地区 北京协和医学院
出处 《国际放射医学核医学杂志》 2009年第2期105-109,共5页 International Journal of Radiation Medicine and Nuclear Medicine
关键词 基因 Gadd45 基因组不稳定性 肿瘤 Gene, Gadd45 Genomic instability Neoplasms
分类号 R730.2 [医药卫生—肿瘤]
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国际放射医学核医学杂志
2009年 第2期

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