基因治疗联合放射治疗恶性肿瘤的分子机制

Molecular mechanism of genetherapy combined radiotherapy for malignant tumor

放射治疗是恶性肿瘤治疗的常规手段之一，对放射治疗的耐受性是影响放疗疗效的主要障碍之一。基因治疗联合放疗代表了恶性肿瘤治疗的一种新方式，在一系列联合治疗的研究中发现，基因治疗可以提高肿瘤的辐射敏感性，减少肿瘤的复发和转移，改善放射治疗的疗效。该文综述肿瘤基因治疗联合放射治疗的有关分子机制。

Radiotherapy is one of the routine treatment methods for malignant tumor. Resistance to radiation is one significant obstacle to the curative effects of radiotherapy. Genetherapy combined with radiotherapy represents a new approach to cancer treatment. A series of studies about combination therapy found that genetherapy could enhance tumor radiosensitivity, reduce recurrence and metastasis, and improve effects of radiotherapy. Review the relevant molecular mechanisms of genetherapy combined radiotherapy for malignant tumor.