泰必利联用羚羊角治疗半面痉挛疗效观察

Tiapride with the horn of saiga tatarica in the treatment of hemifacial spasm

目的:观察泰必利联用羚羊角治疗半面痉挛的疗效。方法:28例原发性半面痉挛患者口服泰必利50mg/次,每日1～3次;加服羚羊角胶囊0.15～0.30g/次,每日1次。必要时泰必利最大剂量可用至100mg/次,每日1～3次。1个月为1个疗程,常规用药不少于3～4个疗程。部分患者持续用药4～6个疗程。用药满3个月后评价疗效。结果:完全缓解8例,明显缓解12例,部分缓解5例,无效3例。总有效率达89.29%。结论:泰必利联用羚羊角治疗半面痉挛疗效肯定、安全性高。

Objective：Tiapride has been used effectively in the clinic for the treatment of dyskinesias and tic disorders including Tourette syndrome. The purpose of the retrospective study is to evaluate the effectiveness of tiapride with the horn of saiga tatariea in treatment of hemifacial spasm. Method： Twenty-eight patients with idio- pathic hemifaeial spasm, who were previously treated with carbamazepine, or acupuncture, or botulinum toxin injection, but refused to continue the previous therapies, were treated with tiapride, at a dosage of 50 mg/time once to thrice per day, combined with the horn of saiga tatarica at a dosage of 0.15 g to 0.30 g/time once per day. The dosage of tiapride can been up to 100 mg/time once to thrice per day in some cases if necessary. The effectiveness of the therapy was evaluated from the time of three months after the beginning of the treatment. The main efficacy parameter was the degree of spasm reduction, that is, the classification of spasm before versus after the treatment. Result：The duration of following up is between 3 months and 12 months. Twenty-five cases out of 28 patients have demonstrated a significant reduction of spasm. Of which, eight cases were completely relieved, 12 cases marked relieved and 5 cases partially relieved. The effective rate is 89.29 %. Conclusion： Tiapride combined with the horn of saiga tatarica was effective and safe in reducing hemifacial spasm. However, further data from blinded trials and long-term following up are required before this treatment can be considered to be one of the main medical treatment options for hemifacial spasm.