应激性胃黏膜损伤发病机制的研究进展

Research progress in mechanism of stress-induced gastric mucosal lesions

应激性胃黏膜损伤(stress-induced gastricmucosal lesions)是由于手术创伤、休克、烧伤等应激引起胃黏膜保护机制与损伤机制发生失衡而出现的以溃疡或糜烂为特征的严重并发症.其病理表现为胃黏膜广泛而表浅的糜烂,发病机制复杂,尚未完全阐明.目前认为是由神经内分泌失调、胃黏膜保护屏障受损、损伤因子增强、细胞凋亡等多因素共同作用的结果.本文对此作一简要综述.

The stress-induced gastric mucosal lesions, appearing as a consequence of surgical trauma, shocks and bums, are serious clinical complication that results in the imbalance between the aggressive factors promoting mucosal damage and the gastric mucosal defense mechanisms. The pathology of stress-induced gastric mucosal lesions show extensive and superficial erosion. Recent studies indicate that stress ulceration is a complex process, and it may be caused by many factors, such as neuroendocrine disorders, gastric mucosal barrier damage, injury factors increase, apoptosis, etc. This paper reviews the pathogenesis of stressinduced gastric mucosal lesions.