摘要
肝星状细胞(hepatic stellate cells,HSCs)是细胞外基质(extra cellular matrix,ECM)的主要来源,在肝纤维化形成中起关键性作用,ECM主要成分包括各型胶原、糖蛋白、蛋白多糖等.HSCs通过分泌多种细胞因子影响并加重肝纤维化的进程.近年国内外围绕以HSCs凋亡和促进胶原的降解为靶标的抗肝纤维化研究成为热点,为肝纤维化的防治寻找突破口.
Extra cellular matrix (ECM), which plays a key role in the formation of liver fibrosis, mainly comes from the hepatic stellate cells (HSCs). The major components of ECM, includes collagens, glycoproteins, polysaccharides, etc. HSCs can influence or accelarate the process of liver fibrosis through secretion of many cytokines. Recently, many scientists home and abroad focus on HSCs apoptosis and degradation of collagen as a target, in order to find a breakthrough for the prevention and treatment of liver fibrosis.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第17期1745-1748,共4页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30760321
广西壮族自治区自然基金资助项目
No.桂科自0542096
广西研究生教育创新计划基金资助项目
No.2008106001006M11~~
关键词
肝星状细胞
细胞外基质
细胞因子
分子机制
Hepatic stellate cells
Extra cellular matrix
Cytokines
Molecular mechanisms