基于肝星状细胞分子机制的抗肝纤维化研究进展

Advances in anti-fibrosis at the molecular level based on hepatic stellate cells

肝星状细胞(hepatic stellate cells,HSCs)是细胞外基质(extra cellular matrix,ECM)的主要来源,在肝纤维化形成中起关键性作用,ECM主要成分包括各型胶原、糖蛋白、蛋白多糖等.HSCs通过分泌多种细胞因子影响并加重肝纤维化的进程.近年国内外围绕以HSCs凋亡和促进胶原的降解为靶标的抗肝纤维化研究成为热点,为肝纤维化的防治寻找突破口.

Extra cellular matrix （ECM）, which plays a key role in the formation of liver fibrosis, mainly comes from the hepatic stellate cells （HSCs）. The major components of ECM, includes collagens, glycoproteins, polysaccharides, etc. HSCs can influence or accelarate the process of liver fibrosis through secretion of many cytokines. Recently, many scientists home and abroad focus on HSCs apoptosis and degradation of collagen as a target, in order to find a breakthrough for the prevention and treatment of liver fibrosis.