新型三元铜配合物的合成、晶体结构及抑菌性能研究

Study on of synthesis,crystal structure and antimicrobial performance of a new-type ternary mixed-ligand copper(Ⅱ) complex

本文合成了新型三元铜配合物[Cu(pht)(Bapo)].(pht)CH3OH(Hpht=苯妥英,Bapo=3-(二(3-氨基丙基)-氨基丙醇)。产物的X-射线单晶衍射数据表明,该配合物属三斜晶系,空间群为PI-,晶胞参数为a=8.526(2),b=14.153(2),c=17.168(3),α=67.464(2)°,β=87.522(3)°,γ=77.039(3)°,V=1862.6(6)3,Z=2,Dc=1.379 g.cm-3,μ(Mo Kα)=0.643 mm-1,F(000)=814,R1=0.0600,wR2=0.1393。在配合物中,中心铜原子的配位环境为变形三角双锥,其中有机多胺配体Bapo表现为{N,N,N,O}四齿配体。配合物通过分子间的O-H…N和N-H…O氢键作用形成三维结构。通过单片滤纸法测定了产物抑菌功能,该配合物对大肠杆菌和金黄色葡萄球菌效果明显。

A new-type ternary mixed-ligand copper（II） complex [Cu（pht） （Bapo）] × （pht） CH3OH （Hpht = 5, 5-diphenylimidazolidinc-2,4-dione, Bapo = 3- （ bis（3-aminopropyl） amino） propanl-ol） was synthesized by hydrothermal method and characterized by elemental analysis and X-ray single-crystal diffraction. The X-ray data showed that the complex was crystallized in the triclinie system with space group PI and cell parameters： a = 8.526（2）, b = 14. 153（2）, c = 17.168（3） A., α = 67.464（2）°, β = 87.522（3）°,γ = 77.039（3）°, V = 1862.6（6）A^3, Z = 2, D, = 1.379 g· cm^-3, μ（MoKa） = 0.643 mm^-1, F（000） = 814, the final R1 = 0.0600,wR2 = 0. 1393. The copper environment for the title complex was a distorted （3 ＋ 2） CuN4O trigonal bipyramid with Bapo acting as a { N, N, N, O} quadridentate ligand. The 3D frameworks were connected by intermolecular O-H…N and N - H…O hydrogen bonds. The antimicrobial function of the title complex was evaluated against a series of bacteria in vitro by filter paper method. The results showed that the title complex was more active against the Escherichia eoli and Staphylococcus Aureus than its precursor Hpht and Cu（Ac）2 ×H2O.