非磺脲类促泌剂对心血管危险因子的裨益

目的研究非磺脲类促泌剂对进食实验餐后的心血管危险因子的作用。方法14例初次单纯饮食控制的2型糖尿病患者经过2周的清洗期,然后进入为期3个月的随机、交叉、平行瑞格列奈(1mg,2次/日)和格列美脲(2mg,1次/日)实验。与磺脲类相比,非磺脲类促泌剂治疗能使进食试验餐后120分钟时的血浆葡萄糖、TG、游离脂肪酸、纤维蛋白原、PAI—1、纤溶酶—a(2)—抗纤溶酶复合物(PAP)、凝血酶—抗凝血酶复合物以及TBARS水平显著降低,而血浆HDL升高。结果与磺脲类促泌剂相比,非磺脲类促泌剂治疗能显著降低游离脂肪酸(r=0.62;P<0.01)、纤维蛋白原、PAI—1(r=0.72;P<0.003)、PAP、凝血酶—抗凝血酶复合物以及TBARS水平,HDL胆固醇增高。结论非磺脲类促泌剂可能对降低心血管危险因素具有裨益。

Objective Studies the non-sulfonylureas to press to Cardiova presses scular dangerous after the feed experiment meal cardiovascular dangerous factor function. Methods 14 example primary pure diet control＇s patients with type 2 diabetes passes through 2 week-long clean time. Then enter the experiment with 3 month-long of Stochastic, overlapping, parallel is Repaglinide （lmg,2/day） to test with the glimeiclamide （2 mg,1/ day）. Compares the non-sulfonylureas with the sulfonylureas to press to secrete the medicinal preparation treatment can cause feed experiment meal after 120 minute when the blood plasma glucose, TG, the free fatty acids, the fibrinogen, PAI-1, PAP, the zymoplasm-anti-zymoplasm compound and the TBARS level obviously reduces, but HDL elevates.Rsults Presses the Peru Jinan non-sulfonylureas with the sulfonylureas to press to secrete the medicinal preparation treatment to be able obviously to reduce the free fatty acids （r=0.62;P〈0.01）, Fibrinogen, PAI-1 （r=0.72;P〈0.003）,PAP, zymoplasm-anti-zymoplasm compound as well as TBARS level, HDL cholesterol markup.Conclusion It is possibly that the non-sulfonylureas presses to Cardiova to reduce the cardiovascular hazard factor to have the benefit.