三唑并嘧啶硫亚甲基三唑硫醚衍生物的合成与生物活性

Synthesis and Biological Activities of Triazolopyrimidine Thiomethylene Triazolothio-Ether Derivatives

以2-巯基-5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶为原料,设计合成了10种含5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶环和1,2,4-三唑环的双杂环硫醚化合物,结构经MS、1HNMR进行表征。初步的生物活性测试表明,在50μg/L质量浓度下,大部分化合物6对甜菜褐斑病菌表现出好的抑制效果,化合物6b、6e、6f、6g和6h抑制效果达到A级(≥90%)。

Ten novel diheterocyclic thio-ether compounds containing 1,2,4-triazolo[1,5-a] pyrimidine and 1,2,4-triazole moieties were designed and synthesized with 2-mercapto-5,7-dimethyl-[1,2,4]triazolo [1,5-a]pyrimidine as starting material.All the compounds obtained were comfired by MS and 1H NMR.Preliminary biological activity test indicates most of compounds 6 display good activity against C.beticola.Especially,compounds 6b,6e,6f,6g and 6h can reach grade A（≥90%） at a concentration of 50 μg/L.