超声辐射在新型含双杂环芳酰基硫脲合成中的应用

Application of Ultrasonic Irradiation in Synthesis of Novel Bis-heterocyclic Aroylthioureas

以2-苯基-1,2,3-三唑-4-甲酸、氨基硫脲为原料在三氯氧磷中反应得到2-氨基-5-(2-苯基-1,2,3-三唑-4-基)-1,3,4-噻二唑,然后分别采用超声辐射法和常规加热法与芳酰基异硫氰酸酯反应合成了一系列的N-[5-(2-苯基-1,2,3-三唑-4-基)-1,3,4-噻二唑-2-基]-N′-酰基硫脲。通过与常规方法比较,采用超声辐射法反应时间只有原来的12.5%,反应产率提高了4%～17%,减少了副反应。所有化合物的结构经元素分析、MS、IR、1H NMR测试技术确证。

2-Amino-5-（2-phenyl-1,2,3-triazol-4-yl）-1,3,4-thiodiazole（1） was prepared by the reaction of 2-phenyl-1,2,3-triazole-4-carboxylic acid with aminothiourea in the presence of phosphorus oxychloride.Then a series of N-[5-（2-phenyl-1,2,3-triazol-4-yl）-1,3,4-thiodiazol-2-yl]-N′-aroylthioureas was synthesized by the reaction of compound 1 with aroyl isothiocyanates by means of ultrasonic radiation method and ordinary method.The reaction time for the first method was about 12.5% that of the second one,and the yield was increased by 4%-17%.The side products were at the same time reduced.The structures of these compounds were confirmed by elemental analysis,MS,IR and 1H NMR spectroscopies.