哈萨克族肥胖与胰岛素抵抗的关系研究

The study of the relationship between obesity and insulin resistance in Kazakans

目的:研究哈萨克族人群肥胖与胰岛素抵抗的关系。方法:以1902例年龄20～82岁哈萨克族成人作为研究对象,测定其身高、体重、腰围(WC)及空腹血糖(FPG)和空腹胰岛素水平(FIns),估算胰岛素抵抗指数(HOMA-IR)与胰岛素敏感指数(ISI),比较上述指标肥胖患者和非肥胖对照人群之间胰岛素抵抗的差异。分析哈萨克族胰岛素抵抗与肥胖发病的关系。结果:肥胖患者较非肥胖者FPG、体重指数(BMI)、WC均显著升高(P<0.05),但ISI显著降低(P<0.01)。结论:肥胖与胰岛素抵抗的关系密切,肥胖的患者存在更为严重的胰岛素抵抗。

Objective： To study the relationship between obesity and insulin resistance （IR） in Kazak popu lation. Methods： One thousand nine hundred and two cases of Kazak adults aged 20-82 years old for the study, height, weight, waist circumference （WC） and fasting plasma glucose （FPG）, fasting insulin levels to estimate insulin resistance index （HOMA-IR） and insulin sensitivity index （ISI） were measured, compared the above indexes in obese patients and non-obese control group the differences between the insulin resistance; the incidence of insulin resistance and obesity relationship in Kazaks were analysed. Results： The FBG, BMI, WC of obese people were significantly higher than non obese people （P 〈0.05）, but the ISI was significantly lower （P 〈0.01）. Conclusions： Obesity and insulin resistance are closely related, the existence of obesity in patients always has more severe insulin resistance.