摘要
研究的目的是制备一种吸附剂用于清除患者血液中大量的类风湿因子,并对制备的吸附剂进行吸附性能评价。首先制备了大孔聚乙烯醇微球载体,经活化后固定苯丙氨酸作为配基形成类风湿因子吸附剂,通过体外静态和动态吸附实验对其吸附性能以及相关的影响因素做系统的评价。结果表明,该吸附剂能够在短时间内快速吸附类风湿因子,具有较高的吸附效率(约60%)和吸附容量(750 IU/mL),适宜用作血液灌流去除类风湿因子的吸附剂。
In order to removal high levels of rheumatoid factors（RFs） from the blood of rheumatoid arthritis patients, macroporous polyvinyl alcohol microspheres was prepared and activated, L-phenylalanine was immobilized as ligand to the beads to form the adsorbent. The adsorption performance of the adsorbent was evaluated in vitro by the static and circulation adsorption methods. The results showed that this kind of adsorbent could remove RFs rapidly and had an excellent adsorption percentage （about 60%）, high adsorption capacity （750 IU/mL）, being suitable for haemoperfusion to remove rheumatoid factors.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2009年第4期561-566,共6页
Chinese Journal of Biomedical Engineering
基金
天津市科技发展计划项目(YFSZSF00800)
