小剂量肾上腺素在肝动脉化疗栓塞中的应用

Effect of the small dose epinephrine in TACE on the liver cancer

目的:探讨肾上腺素在经导管肝动脉化疗栓塞术(transcatheter hepatic arterial chemoembolization,TACE)治疗中晚期肝癌中的应用价值。方法:144例中晚期肝癌患者随机分成2组,治疗组72例,在灌注化疗药物及碘油乳剂前推注小剂量肾上腺素;对照组72例,常规行经导管肝动脉化疗栓塞术,2组所用化疗药物及超液态碘油基本相同。结果:治疗组有效率为61.11%,对照组为36.11%,治疗前后肝肿瘤的变化、术后肝功能变化及对生活质量的影响2组差异有统计学意义(P<0.05)。结论:小剂量肾上腺素经导管灌注可显著减少TACE术后肝功能损害。

Objective： To investigate the application value of adnephrin in TACE on the apud -advanced liver cancer. Methods： 144 patients with apud -advanced liver cancer were randomly divided into two groups, In treatment group of 72 cases, patients were injected small dose of epinephrine prior to the chemotherapy drugs and lipiodol emulsion ; In control group of 72 cases, patients were treated with conventional chemotherapy and embolism, which the chemotherapy drugs and lipiodol ultra liquid were the same basically. Results： The efficiency of the treatment group ,was 61.1%, 36.1% for the control group.The changes of intrahepatic tumor,postoperative liver function and the quality of life had a significant deviation in two groups between pretherapy and post-treatment （P〈0.05）. Conclusion： The small dose epinephrine infusion transcatheter can significantly reduce damage to liver function after TACE.