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p38MAPK信号传导通路与重症急性胰腺炎 被引量：1

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摘要 丝裂原活化蛋白激酶(mitogen-activated proteinkinase,MAPK)信号传导通路是细胞外信号引起细胞反应的共同通路,其中p38MAPK在介导炎症、应激等细胞反应中最为引人注目。本文综述了p38MAPK这一信号传导通路的结构特征、激活与生物学效应,及其在重症急性胰腺炎发病机制中的作用,旨在为重症急性胰腺炎的诊治研究提供新的思路。
作者 刘道利 王东 徐亮
机构地区 绵阳市中心医院消化疾病中心 泸州医学院附属医院普通外科
出处 《中国现代普通外科进展》 CAS 2009年第7期614-615,623,共3页 Chinese Journal of Current Advances in General Surgery
关键词 胰腺炎 急性坏死性 P38丝裂原活化蛋白激酶类 信号传导
分类号 R657.51 [医药卫生—外科学]
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参考文献14

  • 1Zhang P, Martin M, Michalec SM, et al .Role of Mitogen_Activated Protein Kinases and NF-kBin the Regulation of Proinflammatmy and Anti-Inflammatory Cytokines by Porphyromonas gingivalis Hemagglutinin B[J]. Infection and Imnmnity, 2005,73 (7):3990.
  • 2Brewster JL, De Valoir T, Dwyer N, et al. An osmosensing signal transduction pathway in yeast[J]. Science, 1993, 259(5099):1760-1763.
  • 3Brewster JL, De Valoir T, Dwyer N, et al. An osmosensing signal trans- duction pathway in yeast[J]. Science, 1993, 259(5099):1760-1763.
  • 4Han J, Lee JD, Bibbs I, et al. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells [d]. Scienee, 1994,265 (5173):808-811.
  • 5Tenhunen O, Rays J, lives M, et al .Identification of cell cycle regulatory and inflammatory genes as predominant targets of p38 mitogenactivated protein kinase in the heart[J]. Circ Res, 2006,99(5):485.
  • 6Badeger AM, Flradbeer JN, Votta B. Pharmaeologieal profile of SB203580, a selective inhibitor of eytokine suppressive binding protein/p38 kinase in animal model of arthritis bone resorption endotoxin shock and immune function [J]. J Phamlacol Exp Ther, 1996,279(3 ):1453-1461.
  • 7John M, Avruch K J. Mamalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation [J].Physiol Rev, 2001,81 (2):867-869.
  • 8Band S , Singh P, Pooran N, et al. Evaluation of factors that have reduce mortality from acute pancreatitis over the past 20 years[J]. J clin gastrnenterol, 2005,35 (1):50.
  • 9Bidarkundi GK, Wig JD, Bhatnagar A, et al. Clinical relevance of intracellular cytokines IL-6 and IL-12 in acute pancrcatitis, and correlation with APACH Ⅲ score[J]. Br J Biomed Sci, 2002,59(2): 85-89.
  • 10Wagner AC, Metzler W, Hofken T, et al. P38MAP kinase is expressed in the pancreas and is immediately activated following cerulean hyperstimulation[J]. Digestion, 1999,60(1 ):41-47.

二级参考文献15

  • 1Simeone DM, Zhang L, Graziano K, Nicke B, Pham T, Schaefer C, Logsdon CD. Smad4 mediates activation of mitogen-activated protein kinases by TGF- beta in pancreatic acinar cells. Am J Physiol Cell Physiol 2001;281:C311-C319.
  • 2Fleischer F, Dabew R, Goke B, Wagner AC. Stress kinase inhibition modulates acute experimental pancreatitis. World J Gastroenterol 2002;8:259-265.
  • 3Ren HB, Li ZS, Xu GM, Tu ZX, Shi XG, Jia YT, Gong YF. Dynamic changes of mitogen-activated protein kinase signal transduction in rats with severe acute pancreatitis. Chin J Dig Dis 2004;5:123-125.
  • 4Kyriakis JM, Avruch J . Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001;81:807-869.
  • 5Arbabi S, Rosengart MR, Garcia I, Jelacic S, Maier RV. Priming interleukin 8 production: role of platelet-activating factor and p38. Arch Surg 1999;134:1348-1353.
  • 6Clifton AD, Young PR, Cohen P. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAPkinase-3 and their activation by cytokines and cellular stress. FEBS Lett 1996;392:209-214.
  • 7Janknecht R, Hunter T. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. EMBO J 1997;16:1620-1627.
  • 8Beyaert R, Cuenda A, Vanden Berghe W, Plaisance S, Lee JC, Haegeman G, Cohen P, Fiers W. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J 1996;15:1914-1923.
  • 9Dabrowski A, Boguslowicz C, Dabrowska M, Tribillo I, Gabryelewicz A. Reactive oxygen species activate mitogen-activated protein kinases in pancreatic acinar cells. Pancreas 2000;21:376-384.
  • 10O'Neill S, O'Neill AJ, Conroy E, Brady HR, Fitzpatrick JM, Watson RW. Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis. J Leukoc Biol 2000;68:15-20.

共引文献11

同被引文献10

  • 1Terry PD, Rohan T, Wolk A. lntakes offish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormonerelated cancers: a review of epidemiologic evidence[J]. Am J Clin Nutr, 2003,77(3):532-543.
  • 2Connolly JM, Coleman M, Rose DP. Effects of dietary fatty acids on DU145 human prostate cancer cell growth in athymic nude mice[J]. Nutr Cancer, 1997,29(2):114-119.
  • 3Toit-Kohn JL, Louw L, Engelbrecht AM. Docosahexaenoic acid induces apoptosis in colorectal carcinoma ceils by modulating the P13 kinase and p38 MAPK pathways [J]. J Nutr Biochem, 2009,20 (2): 106-114.
  • 4Simona Serini, Sonia Trombino, Francesco Oliva, et al. Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-I and down-regulating p-ERK1/2 and p-p38 expression[J]. Apoptosis, 2008,13(9):1172-1 183.
  • 5Tsai WS, Nagawa H, Kaizaki S. Inhibitory effects of n-3 polyunsaturated fatty acids on sigmoid colon cancer transformmlts [J]. J Gastroenterol, 1998,33(2):206-212.
  • 6Chen ZY, lstfan NW. Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells [J]. Prostaglandins Leukot Essent Fatty Acids, 2000,63 (5):301-308.
  • 7Fisher M, Liu B, Glennon PE, et al. Downregulation of the ERK 1 and 2 mitogen activated protein kinases using antisense oligonucleotides inhihits proliferation of porcine vascular smooth muscle cells[J]. Atheroselrosis, 2001,156(2):289-295.
  • 8Calviello G, Di Nicuolo F, Gragnoli S, et al. n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-lalpha induction pathway[J]. Carcinogenesis, 2004,25 ( 12):2303-2310.
  • 9Mazumder S, Plesca D, Almasan A. Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis [J]. Methanols Mol Biol, 2008,414(1 ):13-21.
  • 10Narayanan BA, Narayanan NK, Reddy BS. Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells[J]. Int J Oncol, 2001,19(6):1255-1262.

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中国现代普通外科进展
2009年 第7期

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