摘要
目的探讨Syk表达情况在直肠癌发生、发展过程中可能的作用机制,为临床诊治直肠癌探讨新的生物学标记物。方法应用免疫组织化学SP法检测Syk在直肠癌组织标本中的表达情况,并应用采用四格表法及χ2检验进行统计学分析对结果进行分析。结果10例癌旁正常组织中Syk全部呈阳性。在50例直肠癌组织标本中发现Syk表达情况在淋巴结转移情况及肿瘤细胞不同分化程度中存在显著性差异,而在患者性别、不同年龄组中表达无显著差异。结论Syk表达的缺失与直肠癌的发生、转移存在密切的关系,推测以Syk作为靶分子进行干预可能对于直肠癌的控制和治疗有一定的临床价值。
Objective To explore the value of expression of Syk in rectum cancer prognosis and its treatment.Methods The expression of Syk in rectum cancer was examined with immunohistochemistry.The staining result was analyzed by using the optical microscope,then investigating the difference between corresponding groups.Results In normal rectum tissue,Syk was positively expressed in all specimens.The negative expression of Syk was associated with lymph nodes transferation and histology stage.On the other hand,the negative expression of Syk wasn＇t associated with sexual distinction and age.Conclusion Syk is closely associated with the growth and transferation of rectum cancer.The Syk has great clinical significance.
出处
《医学研究与教育》
CAS
2009年第4期14-16,共3页
Medical Research and Education
