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环氧化酶-2在大肠癌的表达及相关性研究

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摘要 环氧化酶(cyclooxygenase,COX)是催化花生四烯酸代谢产生前列腺素(Prostaglandins,PGs)的限速酶。近年来大量研究表明诱导型COX-2的过度表达导致的PGs水平升高在人类多种类型肿瘤的发生过程中起重要作用。COX-2其促进肿瘤发生的作用目前已得到公认。近年国内外大量研究表明COX-2不仅通过促进细胞增殖、抑制凋亡参与多种肿瘤的发生过程,而且还可利用不同的途径来促进肿瘤的侵袭与转移。
出处 《医学研究与教育》 CAS 2009年第4期89-92,共4页 Medical Research and Education
基金 2008年河北省卫生厅指导性计划项目(编号:08375)
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