低分子肝素钙联合盐酸氨溴索吸入治疗慢性阻塞性肺疾病急性加重期疗效分析

Low-molecular-weight heparin calcium combined with mucosoivan in the treatment of acute exalerbation of chronic obstructive pulmonary disease

目的观察低分子肝素钙与盐酸氨溴索联合吸入治疗慢性阻塞性肺疾病急性发作期（AECO—PD）的疗效。方法46例AECOPD患者按照就诊顺序分为治疗组24例，对照组22例，对照组患者给予β2-受体激动剂、茶碱类药物、抗生素、糖皮质激素、活血化瘀、吸氧等常规治疗，治疗组在常规治疗基础上加用低分子肝素钙2500IU加生理盐水5ml，盐酸氨溴索注射剂30mg加生理盐水10ml，均2次／d，雾化吸入，比较2组患者临床症状的改善情况、平均住院日等指标。结果2组患者治疗7d后动脉血氧分压、二氧化碳分压及呼气峰流量均较治疗前明显改善（P〈0．01），治疗组平均住院时间为（10±4）d，对照组（14±4）d，组间比较差异有统计学意义（P〈0．05）。结论低分子肝素钙联合盐酸氨溴索吸入治疗AECOPD，临床疗效较好。

Objective To investigate the effect of low-molecular-weight heparin calcium combined with ambroxol on acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods Forty-six patients were divided into the treatment group （n = 24） and control group （n = 22）. In the treatment group, the low-molecular-weight heparin calcium and ambroxol were added in therapy, the other drugs used in the therapy were same in both groups. Remits After treatment, arterial oxygen pressure, cardoon dipjide partial pressure and peak expirato- ry flow of all patients were significantly improved（ P 〈 0.01 ）. The average hospitalization of treatment group [ （ 10 ± 4） d ] was shorter than control group [ （ 14 ± 4） d ] （P 〈 0.05）. Conclusion The inhalation treatment of AECOPD combined with low-molecular-weight heparin Calcium and ambroxol is superior to conventional therapy.