急性腔隙性脑梗死患者血清C-反应蛋白和白介素-8水平的变化及临床意义

Changes of serum high-sensitivity C-reactive protein and interleukin-8 and clinical significance in patients with acute cerebral infarction

目的探讨急性腔隙性脑梗死患者血清高敏C-反应蛋白(hs-CRP)、白介素-8水平(IL-8)的变化及在发病机制中的作用。方法分别检测36例腔隙性脑梗死、36例脑梗死和36例健康对照者血清hs-CRP和IL-8含量。结果腔梗组和脑梗组hs-CRP含量分别为(10.42±0.68)、(18.45±1.28)mg/L,均显著高于对照组的(1.28±0.47)mg/L(P<0.01),CI组hs-CRP含量亦显著高于健康对照组(P<0.01);腔梗组和脑梗组IL-8含量分别为(29.65±18.24)、(36.57±19.01)ng/ml,显著高于对照组的(25.98±16.87)ng/ml(P<0.01),在脑梗患者中,大面积脑梗死(≥9ml)hs-CRP为(21.36±1.48)mg/L,显著高于小面积脑梗死组(<9ml)的(15.30±0.97)mg/L(P<0.01),2组IL-8含量分别为(38.1±19.87)、(33.45±18.67)ng/ml,差异亦有统计学意义(P<0.01)。结论炎症过程参与了脑小血管病变;hs-CRP和IL-8水平与脑缺血程度以及脑的小血管病变范围密切相关。hs-CRP及IL-8是预测脑梗死患者病情严重程度的重要生化指标。

Objective To explore the changes of serum high-sensitivity C-reactive porotein and interleukin-8 （IL-8） in patients with acute lacunar infarction and their roles in pathogenesis. Methods The levels of hs-CRP and IL-8 in patients with acute lacunar infarction （n= 36）,cerebral infarction （n= 36） and healthy controls （n= 36） were measured respectively. Results The levels of hs-CRP in both acute lacunar infarction group and cerebral infarction group were （10. 42±0. 68） and （18.45±1.28） mg/L,respectively. They were significantly higher than that in control group which was （1.28±0. 47）mg/L（P〈 0. 01）. The levels of IL-8 in both acute lacunar infarction group and cerebral infarction group were（29. 65±18.24） and （36.57 ±19.01） ng/L, respectively. They were significantly higher than that in control group which was （25.98±16.87） ng/L （P〈 0. 01）. The levels of both hs-CRP and IL-8 in the cerebral infarction group were higher than those in acute cerebral infarction group （P〈0.01）. In infarction group ,the levels of both hs-CRP and IL-8 in patients with big area infarction were higher than those in patients with small area infarction （P〈0.01）. Conclusion Inflammatory process has involved in the small vascular lesion in brain , the levels of serum hs-CRP and IL-8 are closely correlated with the degree of cerebral ischemia, hs-CRP and IL- 8 are the important biological markers which predict the severity of cerebral infarction.