GnRH-a治疗真性性早熟的临床研究

GnRH-a treatment of precocious puberty in clinical research

目的:观察长效缓释促性腺激素释放激素类似物(GnRH-a)类药物对特发性真性性早熟的短期治疗效果。方法:以曲普瑞林(商品名达菲林)(剂量为体重≥20kg者3.75mg/月,体重<20kg者1.875mg/月)对18例患儿行皮下注射治疗,采用配对资料t检验对患儿治疗前后的各项指标进行比较。结果:女性患儿治疗后94.4%(16/18)乳房回缩,5例有月经者在1个月后即停经;治疗后子宫卵巢明显缩小(P<0.05);黄体生成素(LH)峰值由(18.25±8.28)mIU/ml降至(5.70±1.55)mIU/ml(P<0.001),卵泡刺激素(FSH)峰值由(15.56±8.18)mIU/ml降至(4.53±2.20)mIU/ml(P<0.001),雌二醇(E2)峰值、基础值和LH、FSH基础值的改变无统计学意义;骨龄无明显增加,骨龄/年龄比下降。结论:用长效GnRH-a治疗真性性早熟均能达到快速的实验室和临床抑制效果。

Objective：To observe the long-acting slow-release gonadotropin-releasing hormone analogues （GnRH-a） drugs for idiopathic precocious puberty in the short-term treatment effects, nethods：18 children cases were given subcutaneous treatment with Triptorelin（Proprietary Name：Dafeilin）（Dose： Weight 〉1 20 kg 3.75 mg per month; Weight〈20 kg 1.875 mg per month）. Information on the use of paired t tests on the children of the indicators before and after treatment compared. Results：After treatment, there were 94.4% （16/18）female children breast retraction, five cases of menstruation in one month menopause; uterine and ovarian significantly reduced（P〈0.05）; Luteinizing hormone （LH） peak was from （18.25±8.28） to （5.70±1.55） mIU/ml（P〈0.001）,Follicle-stimulating hormone （FSH） peak was from （15.56±8.18）to（4.53±2.20） mIU/ml（P〈 0.001 ）; but there were no statistical significance in estradiol （E2） peak, the basis of the value of E2, LH and FSH;no significant increase in bone age;bone age/age were all decline. Conclusion： With long-acting GnRH-a treatment of precocious puberty are able to achieve rapid suppression of the laboratory and clinical effects; GnRH-a to be long-term improvement can be expected to achieve the purpose of adult height.