湖北省全球基金艾滋病项目四项目县抗病毒治疗状况比较分析

Evaluation of status of anti-retroviral treatment for HIV/AIDS patients in four Global Fund AIDS Program counties in Hubei Province

目的了解湖北省近几年抗病毒治疗工作的开展情况,以评价湖北省抗病毒治疗状况及效果。方法通过调查艾滋病病人治疗率、服药依从性率及基线和治疗后1～3年CD4+T淋巴细胞变化情况反映抗病毒治疗效果。结果4个项目县的平均治疗率从2005年的43.11%上升到2008年底的72.77%。督导服药覆盖率都在98%以上,但随州、浠水、南漳、巴东的4年平均服药依从率分别为87.6%,99.7%,91.0%和70.3%,不同项目县的4年平均服药依从率差异有统计学意义。经过抗病毒治疗后,患者的CD4水平升高,而且呈现逐年升高的趋势。结论抗病毒治疗提高了患者的CD4水平,但上升趋势逐年减弱。长期抗病毒治疗迫切需要加强和落实患者的服药依从性教育和督导。

Objective To evaluate the efficacy of anti-retroviral treatment for HIV/AIDS patients. Methods The data related to anti-retrovirat treatment such as patient treatment rate, adherence rate of taking medicine, CD4^＋T lymphocytes changes were collected before and after treatment. Results The average treatment rate of selected four global fund program counties increased from 43.11% in 2005 to 72.77 % in 2008. Although the covering rate of surveillance over medicine taking was over 98 %, the average adherence rate of medicine taking in five years of Suizhou, Xishui, Nanzhang, and Badong was 87.6%, 99.7%, 91.0 % and 70.3 %, respectively. After anti-retroviral treatment, the CD4^＋ T lymphoeytes increased compared with those in the baseline, and there was an increasing trend in the past four years. Conclusions Anti/retroviral therapy significantly increases the CD4^＋ T lymphocytes of patients and there was an increasing trend in the past four years. Education and surveillance over adherence of medicine taking by patients remain to be strengthened for longtime anti-retroviral therapy.