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HIV阳性孕产妇的发现时机及接受阻断情况分析 被引量:4

Analysis on diagnostic occasion for HIV positive pregnant women
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摘要 目的通过对HIV阳性孕产妇的发现时机及接受阻断的情况分析,了解当前HIV母婴阻断工作中存在的问题。方法收集在湖北、山西、河北部分县市发现的179名阳性孕产妇(189孕次)发现时机及接受阻断的情况,对所发现的HIV阳性孕产妇未接受综合阻断措施的原因进行分析。结果纳入本研究的项目县,孕检人群HIV阳性率为0.26‰。在发现的HIV阳性孕产妇中产前、产时、产后所占的比例分别为66.7%、7.4%、25.9%,各期发现的HIV阳性孕产妇均有部分未接受综合阻断措施。产前发现未接受抗病毒药物阻断的阳性孕产妇中,个别孕妇不接受药物阻断;产时发现的孕产妇,多数因未获得药物而未用药阻断;而产后才发现的孕产妇则错过了阻断时机。结论我国HIV母婴阻断工作已取得很大成绩,但仍存在HIV阳性孕产妇发现不及时,接受综合阻断措施比率较低等问题,亟需改进。 Objective To understand the existing deficiency in the work of preventing HIV transmission from mother to child. Methods The diagnostic occasions of 179 HIV positive pregnant women (189 pregnant times) in some counties in Hubei, Shanxi, and Hebei were collected, including measures for prevention. The reasons for the missing prevention for HIV positive pregnant women were analyzed. Results The HIV positive rate in pregnant women in the counties enrolled in this study was 0.26‰. Percentage of HIV pregnant women who were found in antepartum, intrapartum, and postpartum were 66.7 %, 7.4 %, and 25.9 % respectively. Some HIV positive pregnant women missed the prevention in all of three periods. In HIV positive pregnant women found antepartum, some rejected prevention. The missing reason for HIV positive pregnant women found intrapartum failed to get ARV drug. HIV positive pregnant women found postpartum missed the prevention. Conelusions There is some progress in the work of preventing HIV transmission from mother to child in China, but some HIV positive pregnant women can not be detected in time, and the percentage of HIV pregnant women who have received comprehensive measures is low. The work of PMTCT therefore needs to be improved.
出处 《中华疾病控制杂志》 CAS 2009年第4期445-447,共3页 Chinese Journal of Disease Control & Prevention
基金 第三轮中国全球基金艾滋病项目(CHN-304-G03-H) 湖北省科技攻关重点项目(2006AA301A02) 香港择善基金会(303235807)
关键词 获得性免疫缺陷综合征 孕妇 母婴传播 Acquired immunodefieiency syndrome Pregnant women Mother to child transmission
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参考文献9

  • 1庄柯,桂希恩,骆嘉拉,王晓榕,苏擘,张永喜.艾滋病高发农村儿童人类免疫缺陷病毒感染与艾滋病发病的关系[J].中华儿科杂志,2003,41(8):586-589. 被引量:15
  • 2Thorne C, Newell ML. Mother-to-child transmission of HIV infection and its prevention [ J ]. Curr HIV Res, 2003,1 (4) : 447- 462.
  • 3Dorenbaum A, Cunningham CK, Gelber RD, et al. Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial [J]. JAMA, 2002,288(2) : 189-98.
  • 4Luzuriaga K, Sullivan JL. Prevention of mother-to-child transmission of HIV infection [J]. Clin Infect Dis, 2005,40(3) :466- 467.
  • 5Zaba BW, Carpenter LM, Boerma JT, et al. Adjusting ante-natal clinic data for improved estimates of HIV prevalence among women in sub-Saharan Africa [J]. AIDS, 2000,14(17) :2741-2750.
  • 6Yahya-Malima KI, Olsen BE, Matee MI, et al. The silent HIV epidemic among pregnant women within rural Northern Tanzania [J]. BMC Public Health, 2006,6 : 109.
  • 7World Health Organization. Antiretroviral drugs for treating pregnant women and preventing HIV infection in infant (2004) [EB/ OL]. http://www.who. int/hiv/pub/mtct/en/arvdrugswomenguidelinesfinal. pdf.
  • 8Bucceri AM, Somigliana E, Matrone R, et al. Combination antiretroviral therapy in 100 HIV-1-infected pregnant women [J]. Hum Reprod , 2002,17(2) :436-441.
  • 9Eshleman SH, Mracna M, Guay LA, et al. Selection and fading of resistance mutations in women and infants receiving nevlrapine to prevent HIV-1 vertical transmission ( HIVNET012 ) [J]. AIDS, 2001,15(15) : 1951-1957.

二级参考文献10

  • 1联合国艾滋病规划署 李晓亮译.1996年6月全球各地区HIV/AIDS流行情况[J].生殖健康与社会科学通讯,1997,1:3-6.
  • 2Sperling RS, Miotti PG, Taha TE, et al. Maternal viral load,zidovudine treament, and the risk of transmission of transmisson of human immunodeficiency virus type 1 from mother to infant. N Engl J Med,1996, 335: 1621-1629.
  • 3Guay LA, Musoke P, fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet, 1999, 354:795-802.
  • 4Mofenson LM,McIntym JA. Advances and research directions in the prevention of mother-to-child HIV-1 transmission . Lancet, 2000,355 : 2237- 2244.
  • 5Pitt J, Brambilla D, Reichelderfer P, et al. Maternal immunologic and virologic risk factors for infant human immunodeficiency virus type 1 infection: findings from the women and infants transmission study. J Infect Dis. 1997. 175: 567-575.
  • 6Dickover RE, Garratty EM, Herman SA, et al. Identification of levels of maternal HIV-1 RNA associated with risk of perinatal transmission.JAMA, 1996, 275: 599-605.
  • 7Langston C, Lewis D, Hammill Ha, et al. Excess intrauterine fetal demise associated with maternal human immunodeficiency virus infection. J Infect Dis, 1995, 172: 1451-1460.
  • 8Oxtoby MJ. Perinatally acquired human immunodeficiency virus infection. Pediatr Infect Dis J, 1999.9: 609-619.
  • 9Landesman SH, Kalish LA, Burns DN, et al. Obstetric1I from mother to child. N Engl J Med, 1996, 334:1617-1623.
  • 10王立秋.全球艾滋病流行进展[J].传染病信息,2003,16(4):147-149. 被引量:12

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同被引文献42

  • 1申洪.免疫组织化学染色定量方法研究(Ⅲ)[J].中国组织化学与细胞化学杂志,1995,4(1):89-92. 被引量:398
  • 2姚璇,彭国平,詹发先,李旺华,张艺,李玲.湖北省HIV感染者/AIDS病人现况分析[J].中国艾滋病性病,2005,11(1):37-39. 被引量:9
  • 3邓莉平,桂希恩,庄柯,苏擘,宁宜云,姜友枝.中国某地区人类免疫缺陷病毒母婴传播与阻断的调查研究[J].中华传染病杂志,2005,23(3):183-186. 被引量:16
  • 4张卫东,郗园林,张梅喜,段广才.血源性艾滋病高发村村民HIV/HBV/HCV混合感染状况调查[J].郑州大学学报(医学版),2006,41(2):254-256. 被引量:11
  • 5Su B, Liu L, Wang F, et al. HIV-1 subtype B' dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China [J]. AIDS, 2003,17(17) :2515-2520.
  • 6Ziegler JB, Cooper DA, Johnson RO, et al. Postnatal transmission of AIDS associated retrovirus from mother to infant [ J ]. Lancet, 1985,1 (8434) :896-898.
  • 7Kaufman J, Jing J. China and AIDS--the time to act is now [J]. Science, 2002,296(5577) :2339-2340.
  • 8Zhang L, Chen Z, Cao Y, et al. Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china [ J ]. J Virol, 2004,78(4) : 13591-13599.
  • 9Nduati R, John G, Mbori-Ngacha D, et al. Effect of breastfeeding and formula feeding on transmission of HIV-1 : a randomised clinical trial [J]. JAMA, 2000,283(9) : 1167-1174.
  • 10Breastfeeding and HIV International Transmission Study Group, Colltsoudis A, Dabis F, et al. Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis [J]. J Infect Dis, 2004,189(12):2154-2166.

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