抑郁症患者治疗前后血浆孤啡肽的研究

The plasma orphanin FQ in patients with depression before and after treatment

目的探讨抑郁症患者治疗前后血浆孤啡肽（OFQ）含量的变化。方法采用放射免疫技术对38例抑郁症患者（患者组）治疗前和治疗第8周末进行血浆OFQ含量测定，并与32例正常人（对照组）进行比较。结果患者组治疗前OFQ含量[（21．9±2．3）ng／L]均高于治疗第8周末[（10．9±2．1）ng／L]及对照组[（10．2±1．8）ng／L]，差异均有统计学意义（t值分别为141．01和23．15，P均〈0．01）。治疗第8周末OFQ含量与对照组的差异无统计学意义。治疗前OFQ含量与汉密顿抑郁量表（24项，HAMD）总分呈正相关（r=0．857，P〈0．01），治疗前后OFQ含量变化亦与HAMD总分改变呈正相关（r=0．342，P〈0．05）。结论抑郁症患者可能存在OFQ水平变化。

Objective To explore the changes of plasma orphanin FQ （OFQ） level in depressive patients before and after treatment. Methods The plasma OFQ levels of 38 depressive patients were determined with radioimmunoassay at baseline and after 8 week antidepressant treatment, and 32 healthy persons were examined once as controls. Resets The concentrations of OFQ in patients were significantly higher at baseline than after treatent and in controls [ （21.9 ± 2. 3 ）ng/L vs. （ 10. 9 ± 2. 1 ）ng/L; （21.9 ± 2. 3） ng/L vs. （10. 2 ± 1.8）ng/L; all P 〈 0. 01 ]. There were no significant differences in OFQ between patients after treatment and in controls. The OFQ concentration in patients at baseline was positively correlated to the scores of 24-items Hamilton Depression Scale （HAMD） （r = 0. 857, P 〈 0. 01 ） , the change of OFQ concentration between baseline and after treatment was also positively correlated to the alteration of HAMD scores （ r = 0. 342, P 〈 0. 05）. Conclusions The results suggest that the alteration of OFQ may be involved in depression.