双相障碍与脑源性神经营养因子的研究进展
被引量：1
摘要
双相障碍是一种严重的、复杂的、呈家族性发病的精神疾病。国外研究资料显示，心境障碍的终生患病率为5．5％-7．8％。尽管临床实践和相关科研已为认识这种疾病积累了大量的证据，但其病因和发病机制仍所知不多。近年来，基于大量的研究结果提出的全新的神经发生（neurogenesis）假说认为，神经的发生不仅存在于胚胎时期，且贯穿整个生命过程。如果神经发生过程出现障碍或受到抑制，则可产生多种中枢神经系统疾病。该假说的依据包括：（1）多项临床试验和长期临床实践显示有药物“滞后起效”，
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2009年第3期179-181,共3页
Chinese Journal of Psychiatry
参考文献14
-
1Kuipers SD, Bramham CR. Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy. Curt Opin Drug Discov, 2006,9: 580-586.
-
2Xu H, Qing H, Lu W, et al. Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus. Neuroscience Letters, 2002, 321: 65-68.
-
3Kanazawa TE, Glatt SJ, Kia-Keating B, et al. Meta-analysis reveals no association of the Va166Met polymorphism of brainderived neurotrophic factor with either schizophrenia or bipolar disorder. Psychiatric Genetics, 2007, 17 : 165-170.
-
4Rybakowski A, Borkowska PM, Czerski MP, et al. Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord, 2003, 5 : 468-472.
-
5Geller JA, Badner R, TiUman SL, et al. Linkage disequilibrium of the brain-derived neurotrophie factor Va166Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry, 2004, 161 : 1698-1700.
-
6Skibinska M, Hauser J, Czerski MP, et al. Association analysis of brain-derived neurotrophic factor (BDNF) gene Va166Met polymorphism in schizophrenia and bipolar affective disorder. W J Bio Psychiatry, 2004, 5: 215-220.
-
7Green EK, Raybould R,MacGregor S, et al. Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: caso-contml study of over 3000 individuals from the UK. Br J Psychiatry ,2006,188 : 21-25.
-
8Sklar P, Gabriel SB, McInnis MG, et al. Family-based association study of 76 candidate genes in bipolar disorder: brain- derived neutrophic factor(BDNF) is a potential risk locus. Mol Psychiatry, 2002, 7: 579-593.
-
9Muller DJ, Luca DV, Sicard T. The brain derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder. Br J Psychiatry, 2006, 189: 317-323.
-
10Tuszynski MH, Gage FH. Neurotrophic factors and diseases of the nervous system. Ann Neurol, 1994, 35: 9-12.
同被引文献25
-
1金卫东,陈震.如何识别尚无躁狂发作的双相障碍?——介绍一种新概念:“软双相”[J].临床精神医学杂志,2005,15(4):249-250. 被引量：11
-
2Rif S.El-Mallakh,Rena Li.双相情感性精神障碍患者应用抗抑郁药治疗的不良后果[J].中华精神科杂志,2005,38(4):251-253. 被引量：5
-
3王筱兰,侯钢.双相情感障碍混合状态的研究进展[J].国际精神病学杂志,2006,33(3):167-170. 被引量：7
-
4王筱兰,侯钢,张心保.双相情感障碍混合相临床特征对照研究[J].临床精神医学杂志,2006,16(5):273-275. 被引量：3
-
5金卫东.双相心境障碍混合状态二例报告[J].山东精神医学,2006,19(4):320-320. 被引量：1
-
6Schwartzmann AM, Amaral JA, Lssler C, et al. A clinical study comparing manic and mixed episodes in patients with bipolar disorder[ J ]. Rev Bras Psiquiatr, 2007,29 ( 2 ) : 130 - 133.
-
7Benazzi F. Challenging the unipolarbipolar division : Does mixed depressionbridge the gap[ J]. Progress in Neuro-Psychopharmacology& Biological Psychiatry,2007,31 ( 1 ) :97 - 103.
-
8初晓译.精神科药物治疗手册[M].北京:人民卫生出版社,2008:121.
-
9Ortiz- Domnguez A, Alda M. Genetic studies of bipolar disorder in patients selected by their treatment response[ J]. Salud Mental,2008, 31(4) :431 -440.
-
10Ghanshyamn, Pandey, Ph, d, hooriyah S, et al. Brain - derived neurotrophic factor gene expression in pediatric bipolar disorder: effects of treatment and clinical response[ J ]. Am J Psychiatry, 2008,47 (9): 1077 - 1085.
-
1潘凤华,丁新生.SNCA基因多态性与帕金森病[J].临床神经病学杂志,2013,26(3):231-233. 被引量：7
-
2陈彪,刘焯霖,王枫.中国帕金森病遗传研究进展[J].中华神经科杂志,2005,38(3):160-164. 被引量：9
-
3王大力,赵晓晶,张江,常莉莎,彭延波,邢磊.原发性癫合并特发性震颤1家系报告[J].临床神经病学杂志,2007,20(5):333-333.
-
4刘湘源,黄烽,李胜光,樊建峰,漆军.红斑肢痛症家族性发病六例并文献复习[J].中华风湿病学杂志,2002,6(6):450-452. 被引量：8
-
5双相障碍早期治疗中断发生普遍[J].家庭药师,2012(11):11-11.
-
6丁惠扬,李德龙,耿福儒,郁开朗.精神分裂症100例脑CT结果与临床[J].中国民康医学,1997,12(3):164-165. 被引量：1
-
7谭启富.我国癫痫外科发展之管见[J].中国临床神经外科杂志,2006,11(8):449-449. 被引量：2
-
8王立洁,尹素华.急诊外伤性肝脾破裂手术的护理体会[J].中国医学创新,2011,8(7):106-107. 被引量：5
-
9叶群荣,胡纪源,韩咏竹,杨任民,陈林,张杰,许亚运.惊愕性癫痫一家系临床报道并文献复习[J].安徽医学,2013,34(10):1470-1473.
-
10叶尘宇,许烨勍,胡华,禹顺英,汪栋祥,施慎逊,王立伟.脑源性神经营养因子基因多态性与双相障碍的关联[J].中华医学杂志,2009,89(27):1897-1901. 被引量：2
