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抑郁症的影像遗传学研究进展 被引量：4

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摘要 抑郁症是一种常见的、威胁生命安全的慢性疾病，患病率约为10％，15％的抑郁症患者自杀身亡。世界卫生组织预测，至2020年，抑郁症将成为非衰老性死亡和残疾的第2大原因，并将跃居全球疾病负担的第2位。为有效地防治抑郁症，人类一直在探寻其具有高度一致性的病理生理学机制。人类基因序列图谱的绘制完成及功能磁共振成像（functional magnetic resonance imaging，fMRI）技术的快速发展，为认识功能基因序列的变异对人类生物学特性的影响提供了巨大帮助。抑郁症患者多存在大脑高级认知及情感信息处理过程的功能障碍，其基因多态性与主观评估症状的相关性较小，
作者 侯正华 袁勇贵
机构地区 南京医科大学附属南京脑科医院精神科
出处 《中华精神科杂志》 CAS CSCD 北大核心 2009年第3期185-187,共3页 Chinese Journal of Psychiatry
基金 南京市医学重点科技发展项目（zkx07018）
关键词 抑郁症 遗传学 病理生理学机制 功能磁共振成像 影像 世界卫生组织 基因序列 生物学特性
分类号 R686 [医药卫生—骨科学]
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参考文献36

  • 1Davison GC, Neal JM, Kring AM. Abnormal Psychology. 9th edition. New York:John Wiley & Sons, Ins. 2004:267-317.
  • 2Holden C. Global survey examines impact of depression. Science, 2000, 288:39-40.
  • 3Murray CJ. Global and regional descriptive epidemiology of disability: incidence, prevalence, healthy expectancies and years lived with disability//Murray CJ, Lopez AD. The global burden of disease. Global burden of disease and injury series, Vol I. Cambridge, MA : Harvard University Press, 1997 : 201-246.
  • 4Hariri AR, Weinberger DR. Imaging genomics. Br Med Bull, 2003, 65: 259-270.
  • 5袁勇贵,张志珺.影像基因组学在精神疾病研究中的应用[J].中华精神科杂志,2007,40(4):248-250. 被引量：6
  • 6Lu B, Gottschalk W. Modulation of hippocampal synaptic transmission and plasticity by neurotrophins. Prog Brain Res, 2000, 128: 231-241.
  • 7Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci, 1995, 15: 7539- 7547.
  • 8Berton O, Mechmg CA, Dileone RJ, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science, 2006, 311: 864-868.
  • 9Egan MF, Kojima M, Callicott JH, et al. The BDNF Va166Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 2003, 112:257- 269.
  • 10Hariri AR, Goldberg TE, Mattay VS, et al. Brain-derived neumtrophic factor Va166Met polymorphism affects human memory- related hippocampal activity and predicts memory performance. J Neurosci, 2003, 23 : 6690-6694.

二级参考文献22

  • 1Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science, 2001, 291:1304-1351.
  • 2Hariri AR, Weinberger DR. Imaging genomics. Br Med Bull, 2003, 65:259-270.
  • 3Glatt CE, Freimer NB. Association analysis of candidate genes for neuropsychiatrie disease: the perpetual campaign. Trends Genet, 2002, 18:30%312.
  • 4Bookheimer SY, Strojwas MH, Cohen MS, et al. Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med, 2000, 343:450-456.
  • 5Bondi MW, Houston WS, Eyler LT, et al. fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease. Neurology, 2005, 64:501-508.
  • 6Lind J, Ingvar M, Persson J, et al. Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon4 carriers. Neuroreport, 2006, 17 : 1683-1686.
  • 7Filbey FM, Slack KJ, Sunderland TP, et al. Functional magnetic imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults. Neuroreport, 2006, 17 : 1585-1590.
  • 8Wishart HA, Saykin AJ, Rabin LA, et al. Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele. Am J Psychiatry, 2006, 163: 1603- 1610.
  • 9Trivedi MA, Schmitz TW, Ries ML, et al. Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study. BMC Med, 2006, 4:1.
  • 10Egan MF, Goldberg TE, Kolachana BS, et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A, 2001, 98:6917-6922.

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中华精神科杂志
2009年 第3期

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