阻塞性睡眠呼吸暂停低通气综合征患者血清心型脂肪酸结合蛋白和高敏C反应蛋白的变化及意义

Changes and implication of serum heart type fatty acid binding protein,high-sensitivity C-reactive protein in patients with obstructive sleep apnea hypopnea syndrome

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清心型脂肪酸结合蛋白(h-fabp)和超敏C反应蛋白(hsCRP)的表达水平及意义。方法选择经多导睡眠仪监测确诊的42例OSAHS患者(OSAHS组)和健康自愿者30例(对照组),采用酶联免疫吸附测定(ELISA)法检测两组血清h-fabp、hsCRP的表达水平,同时常规检测血清天冬氨酸转氨酶(AST)、肌酸激酶(CK)的水平。结果OSAHS组与对照组比较血清h-fabp的水平(11.73±3.45)μg/L vs(7.79±2.84)μg/L;hsCRP(5.41±1.83)mg/L vs(2.49±0.75)mg/L,差异均有统计学意义(均P<0.01);OSAHS组血清AST、CK水平与对照组比较差异无统计学意义(均P>0.05);OSAHS组h-fabp与呼吸暂停低通气指数(AHI)无相关性(r=0.246,P>0.05),而hsCRP与AHI呈正相关(r=0.656,P<0.01)。结论h-fabp、hsCRP联合检测与传统的心肌损害指标相比,对OSAHS患者发生心肌损害和未来心血管事件可能具有更高的预测价值。

Objective To explore the changes and implication of serum heart type fatty acid binding protein （h-fabp） ,high-sensitivity C-reactive protein （hsCRP） in patients with obstructive sleep apnea hypopnea syndrome （（）SAHS）. Methods 42 patients with OSAHS （OSAHS group） were selected by polysomnograshy（PSG） test and 30 healthy subjects（control group） were included. The levels of h-fabp, hsCRP were detected by ELISA, while serum creatine kinase（CK）,aspartate transaminase（AST） were detected with regular methods. Results The levels of serum h-fabp,hsCRP in OSAHS group and control group were of statistic difference,（11. 73±3.45）ug/L vs （7.79±2.84） ug/L,（5.41±1.83） mg/L vs （2.49±0.75） mg/L both （both P〈0.01）. No significant difference was found in serum AST,CK between OSAHS group and control group （both P 〉0.05）. Serum h-fabp level in patients with OSAHS did not correlate significantly with apnea-hypopnea index（AHI） （ r = 0. 246, P 〉0.05）, but hsCRP correlated positively with AHI（ r = 0. 656, P 〈 0.01 ）. Conclusion In comparison with traditional test indices for myocardial damages, combined test on serum h-fabp and hsCRP are of more important values in predicting the likelihood of the myocardial damages and future cardiovascular events in OSAHS.