46例乳腺癌患者脑转移时间及生存时间的预后分析

Prognostic Predictors for Breast Cancer Patients on Interval and Survival of Brain Metastasis

目的:探讨乳腺癌脑转移患者脑转移时间及生存时间的预后因素。方法:选择2004年1月至2008年12月收治的乳腺癌脑转移患者46例,统计脑转移间隔时间及脑转移后存活时间,用Kap-lan-Meier法,log-rank检验,分析脑转移时间及脑转移后生存时间的预后因素。结果:乳腺癌患者出现脑转移的中位时间是36月,手术,化疗,尤其是蒽环类药物化疗后患者脑转移间隔时间较长;脑转移后中位生存时间为10月,手术,化疗,尤其是含蒽环类药物的化疗,放疗以及化疗联合放疗患者存活时间较长。结论:手术,放疗,化疗,蒽环类药物是脑转移生存时间和脑转移时间的预后因素。

Objective： To identify the prognostic predictors for breast cancer patients on interval and survival of brain metastasis. Method： 46 patients were analysed from Jan. 2004 to Dec. 2008. Calculated the interval and survival of brain metastasis by month. The data were analysed by Kaplan - Meier combining with logrank test. Result： For the entire cohort , the median interval between diagnoses and brain metastases was 36 months. Those with surgery, chemotherapy, especially chemotherapy with ADM, were the longer intervals. The median survival after brain metastases was 10 months. Those with surgery, chemotherapy, especially chemotherapy with ADM, radiotherapy, chemotherapy combining radiotherapy were the longer survivals. Conclusion： Surgery, chemotherapy, ADM were prognostic factors of brain metastasis interval and brain metastasis survival.