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Notch信号通路在胃肠道肿瘤发生中的作用

Notch Signaling Pathway in the Pathogenesis of Gastrointestinal Tumors
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摘要 Notch信号通路是影响细胞命运的重要通路之一,相邻细胞之间通过Notch受体与配体的相互作用传递信号,可调节包括干细胞在内的多种细胞的分化、增殖和凋亡。除在正常组织、细胞的分化、发育中发挥重要作用外,Notch信号通路还参与了肿瘤的发生、发展,并在不同肿瘤中呈现促癌或抑癌作用。深入研究Notch信号通路可能为胃肠道肿瘤的基因治疗提供新的靶点。 Notch signaling pathway is one of the key pathways in cell fate determination. Notch signals are transferred between neighboring cells through Notch receptors and ligands, which regulate the differentiation, proliferation and apoptosis of various types of cells, including stem cells. It plays an important role not only in the differentiation and development of normal organs and cells, but also in the development and progression of tumors. Notch signaling pathway has oncogenic or anti-oncogenic effect in different tumors. It might be a novel target for gene therapy of gastrointestinal tumors.
作者 赵恩昊 刘骅 曹晖
机构地区 上海交通大学医学院附属仁济医院普外科
出处 《胃肠病学》 2009年第7期432-434,共3页 Chinese Journal of Gastroenterology
关键词 受体 NOTCH 信号传导: 胃肠肿瘤 Receptors, Notch Signal Transduction Gastrointestinal Neoplasms
分类号 R735 [医药卫生—肿瘤]
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参考文献28

  • 1Ellisen LW, Bird J, West DC, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell, 1991, 66 (4): 649-661.
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二级参考文献35

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共引文献36

胃肠病学
2009年 第7期

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