非酒精性脂肪性肝病的药物治疗进展

Current Pharmacologic Treatment of Nonalcoholic Fatty Liver Disease

非酒精性脂肪性肝病(NAFLD)主要表现为肝实质细胞脂肪变性和脂肪沉积,可在脂肪肝、肝炎基础上进展为肝纤维化和肝硬化,甚至出现肝衰竭或其他并发症。因此有必要在调整生活方式的同时加以药物干预。治疗NAFLD的药物大致分为三类:控制危险因素的药物、利胆保肝药和中药。本文主要就NAFLD的药物治疗作一概述。

Nonalcoholic fatty liver disease （NAFLD） mainly presents as hepatic steatosis and fat deposition. NAFLD can progress to liver fibrosis and cirrhosis, even hepatic failure and other complications. Therefore it is necessary to give pharmacologic treatment in addition to life-style modification. There are three kinds of drugs including drugs for controlling risk factors, hepatoprotective agents and traditional Chinese medicine. This article reviewed the pharmacologic treatment of NAFLD.