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辅助生殖技术与基因印记的关系 被引量：2

The assisted reproductive technology and genomic imprinting
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摘要 随着辅助生殖技术(ART)的迅速发展,ART出生儿越来越多,其应用的安全性问题也受到大家关注。国外的随访研究发现ART出生儿中罕见的印记异常疾病明显增多,之后很多研究证实多种ART会引起印记基因的异常。本文从基因印记的概念、基因印记异常疾病以及ART对印记基因的影响三方面来阐述ART与基因印记的关系。 More and more infertile couples got babies through the rapidly developed assisted reproductive technology in recent years. The safety of these techniques became one of the research hotspots. Recent studies have suggested a link between the use of assisted reproductive technology and an increase incidence of ordinarily rare imprinting disorders. The conception of genomic imprinting, the imprinting disorders, and the link between assisted reproductive technology and genomic imprinting defects were reviewed in this article.
作者 王增艳 徐苓 何方方
机构地区 中国医学科学院北京协和医学院
出处 《生殖医学杂志》 CAS 2009年第4期414-418,共5页 Journal of Reproductive Medicine
关键词 基因印记 辅助生殖技术 Genomic imprinting Assisted reproductive technology
分类号 R321-33 [医药卫生—人体解剖和组织胚胎学] R394 [医药卫生—医学遗传学]
  • 相关文献

参考文献37

  • 1Andersen AN, Goossens V, Gianaroli L, et al. Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE [J]. Hum. Reprod, 2007, 22(6) :1513-1525.
  • 2DeBaun MR, Niemitz EL, Feinberg AP. Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19[J]. Am J Hum Genet, 2003, 72(1):156-160.
  • 3Maher ER, Brueton LA, Bowdin SC, et al. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART) [J].J MedGenet, 2003, 40(1).62-64.
  • 4Halliday J, Oke K, Breheny S, et al. Beckwith-Wiedemann syndrome and IVF: a case-control study[J]. Am J Hum Genet, 2004, 75(3):526-528.
  • 5Cox GF, Burger J, Lip V, et al. Intracytoplasmic sperm injection may increase the risk of imprinting defects[J]. Am J Hum Genet, Z002, 71(1) :162-164.
  • 6Φrstavik KH, Eiklid K, van der Hagen CB, et al. Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmie semen injection[J]. Am J Hum Genet, 2003, 72(1) 218-219.
  • 7Luedi PP, Dietrich FS, Weidman JR, et al. Computational and experimental identification of novel human imprinted genes[J].Genome Res, 2007, 17(12) :1723-1730.
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  • 10胡燕军,黄荷凤.卵母细胞基因组印迹与辅助生殖技术[J].国际生殖健康／计划生育杂志,2008,27(5):279-282. 被引量：1

二级参考文献20

  • 1[1]Morison IM,Ramsay JP,Spencer HG.A census of mammalian imprinting[J].Trends Genet,2005,21(8):457-465.
  • 2[2]Hajkova P,Erhnrdt S,Lane N,et al.Epigenetic repmgramming in mouse primordial germ cells[J].Mech Dev,2002,117(1-2):15-23.
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  • 5[5]El-Maarri O,Buiting K,Peery EG,et al.Maternal methylation imprints on human chromosome 15 are established around or after fertifisation[J].Nat Genet,2001,27(3):341-344
  • 6[6]Arima T,Hata K,Tanaka S,et al.Loss of the maternal imprint in Dnmt3Lmat-/-mice leads to a differentiation defect in the extraemhryonic tissue[J].Dev Biol,2006,297(2):361-373.
  • 7[7]Stier S,Neuhans T,Albers P,et al.Loss of imprinting of the insulinlike growth factor 2 and the H19 gene in testicular seminomas detected by real-time PCR approach[J].Arch Toxicol,2006,80(10):713-718.
  • 8[8]Cox GF,Burger J,Lip V,et al.Intracytoplusmic sperm injection may increase the risk of imprinting defects[J].Am J Hum Genet,2002,71(1):162-164.
  • 9[9]Orstavik KH,Eiklid K,van der Hagen CB,et al.Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplesmic semen injection[J].Am J Hum Genet,2003,72(1):218-219.
  • 10[10]Halliday J,Oke K,Breheny S,et al.Beckwith-Wiedemann syndrome and IVF:a case-control study[J].Am J Hum Genet,2004,75(3):526-528.

同被引文献22

  • 1Barker DJ,Osmond C.Infant mortality,childhood nutrition,and ischaemic heart disease in England and Wales[J].Lancet,1986,1:1077-1081.
  • 2Bloise E,Feuer SK,Rinaudo PF.Comparative intrauterine development and placental function of ART concepti:implications for human reproductive medicine and animal breeding[J].Hum Reprod Update,2014,20:822-839.
  • 3Díaz P,Powell TL,Jansson T.The role of placental nutrient sensing in maternal-fetal resource allocation[J].Biol Reprod,2014,91:82.
  • 4Grafodatskaya D,Cytrynbaum C,Weksberg R.The health risks of ART[R].EMBO Rep,2013,14:129-135.
  • 5Bay B,Mortensen EL,Kesmodel US.Assisted reproduction and child neurodevelopmental outcomes:a systematic review[J].Fertil Steril,2013,100:844-853.
  • 6Eisenberg E.Long-term outcomes in children born after assisted conception[J].Semin Reprod Med,2012,30:123-130.
  • 7Feuer SK,Camarano L,Rinaudo PF.ART and health:clinical outcomes and insights on molecular mechanisms from rodent studies[J].Mol Hum Reprod,2013,19:189-204.
  • 8Shankaran S.Outcomes from infancy to adulthood after assisted reproductive technology[J].Fertil Steril,2014,101:1217-1221.
  • 9Ceelen M,van Weissenbruch MM,Vermeiden JP,et al.Cardiometabolic differences in children born after in vitro fertilization:follow-up study[J].J Clin Endocrinol Metab,2008,93:1682-1688.
  • 10Haavaldsen C,Tanbo T,Eskild A.Placental weight in singleton pregnancies with and without assisted reproductive technology:apopulation study of 536 567pregnancies[J].Hum Reprod,2012,27:576-582.

引证文献2

二级引证文献4

生殖医学杂志
2009年 第4期

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