1Chuzhin Y, Reddy B, Budhai L, et al. Prolonged survival in murine SLE by adenoviral mediated CTLA4Ig gene transfer [ J]. Arthritis Rheum, 1998,41 (suppl) :140.
2Tyndall A. Immunoablation and haemopoietic stem cell transplantation for severe autoimmune disease with special reference to systemic lupus erythematosus [ J]. Lupus ,2001,10(3):214 - 215.
5Kim KM, Min HY, Jung SH, et al. Characterization of an immunosup-pressive anti -CD40 ligand monoclonal antibody [J]. Hybridoma, 1998,17(5) :463 -470.
6Wang X, Huang W, Mihara M,et al. Mechanism of action of combined shortterm CTLA4Ig and anti -CD40 ligand in murine systemic lupus erythematosus [J]. J Immunol,2002,168(4) :2046 -2053.
7Daikh DI, Wofsy D. The immune response to anti - B7 antibodies is dose dependent: low doses elicit a potent response while high doses block the immune response [J]. Arthritis Rheum,1996,39:106.
8Strand V ,Lee M. Intravenous immunoglobulin in the treatment of autoimmune disease. In Strand V, Scott DL, Simon LS: Novel therapeutic agents for the treatment of autoimmune disease [J]. New York, Dekker, 1997,235 - 256.
9Hepburn B, Furie R, Cash J, et al. Reduction of anti - dsDNA antibodies using LIP 394 in patients with lupus [ J ]. Arthritis Rheum, 1996, 39:303.
10Gaynor B, Putterman C, Valadon P, et al. Peptide inhibition of glomerular deposition of an anti - DNA antibody [J]. Proe Natl Aead Sci USA, 1997,94(5 ) :1955 - 1960.
5Ruiz-lrastorza G, Khamashta MA, Castel lino, et al. Sysetemic lupus erythematosus [J]. Lancet,2001,357(9261): 1027-1032.
6Ruckemann K, Fairbanks LD, Carrey EA, et al. Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated Tlymphocytes from healthy humans[J]. JBiolCh e,1998,273(34):21682-21691.
7Urushibam M, Takayamagi H, Koga T, et al. The antirheumatic drug leflunmide in hibits osteoclastogenesis by interfering with receptor activator of NF-kB ligand- stimulated induction of nuclear factor of activated T cells[J]. Arthritis Rheum,2004,50 (3):794-804.
8KraanMC, ReeceRJ, BargEC, et al.Modulation of inflammation and metallopteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis[J]. Athrit is Rheum, 2000,42(8): 1820-1830.
5Hochberg M C.Updating the matology revised criteria American College of Rheu- for the classification ofsystemic lupus erythematosus.Arthritis Rheum,1997,40 (9) : 1725.