Aml1基因异常与儿童急性白血病相关研究进展

Aml1 Gene Abnormlity in Pediatric Acute Leukemia——Review

诸多研究发现细胞遗传学改变在急性白血病发生中起重要作用。其中以涉及aml1基因的改变最为常见。aml1基因为正常造血必需基因之一,在儿童急性白血病中约1/3以上的患儿可以检测到aml1基因的异常,其中t(12;21)和t(4;21)主要见于儿童急性淋巴细胞白血病。期望通过对儿童急性白血病中aml1基因易位的研究,能够揭示儿童急性白血病发生的机制,为儿童急性白血病的临床诊断治疗提供新的靶点。本文就aml1基因的结构与功能,儿童急性淋巴细胞白血病中aml1基因异常和儿童急性髓系白血病中aml1基因异常等问题的研究进展作一综述。

Acute leukemia, the most common cancer in childhood, affects children＇s health severely, whereas the pathogeny and mechanism have not been elucidated clearly yet. As many studies showed, it has been found that transformation of cytogenetics plays a crucial role in leukemia development, and is frequently involved in the transforming action of amll gene, one of which is essential for regulation of normal haematogenesis. Moreover, in children acute leukemia, more than one third children with acute leukemia can be detected with dysfunction of the aml1 gene. Our findings highlight the translocation of amll geue in children acute leukemia, indicating its mechanism, especailly provide a new target for clinical diagnosis and therapy. In this review, the structure and function of amll gene, the abnormality of aml1 gene in acute lymphocytic leukemia, abnotmality of atoll gene in acute myloid leukeima and so on were summrized.