造血干细胞移植后的急性肾衰竭

Acute Renal Failure after Hematopoietic Stem Cell Transplantation——Review

急性肾衰竭(acute renal failure,ARF)是造血干细胞移植后的常见并发症之一,并且与患者的预后密切相关。目前干细胞移植可分为3种类型:清髓性自体干细胞移植、清髓性异基因干细胞移植和非清髓性异基因干细胞移植。本文对这3种移植方式中ARF的发生率、发病机理、严重程度以及对患者预后的影响作一综述。

Hematopoietic stem cell transplantation is a common procedure for the treatment of hematologic malignancies and some non-malignant hematologic disorders. In addition to other transplant-related organ toxicities, acute renal failure is a common complication following allogenaic hematopoietic stem cell transplantation. This review discusses the incidence, etiology, risk factors, and prognosis of renal failure associated with three commonly used transplantation models： myeloablative autologdus, myeloablative allogeneic, and non-myeloablative allogeneic hematopoietic stem cell transplantations.