一种新的联苯胺希夫碱的合成

Synthesis of a Novel Benzidine Schiff Base

文章以2,2-二(4-羟基苯基)丙烷为原料通过Reimer-Tiemann反应合成了2-(3-甲酰基-4-羟基苯基)-2-(4-羟基苯基)丙烷,收率36.4%。再以无水乙醇为溶剂,与联苯胺缩合生成一种新希夫碱,收率89.9%。最佳反应条件是2-(3-甲酰基-4-羟基苯基)-2-(4-羟基苯基)-丙烷与联苯胺的比例为3∶1,反应时间为1h,反应温度为30℃。2-(3-甲酰基-4-羟基苯基)-2-(4-羟基苯基)-丙烷和希夫碱的结构通过IR,1HNMR测定。

2-（3-formyl-4-hydroxyphenyl）-2-（4-hydroxyphenyt）propane was synthesized from 2,2-bis（4-hydroxyphenyl）propane by Reimer-Tiemann reaction, and was then condensed with benzidine to give a new schiff base, with yields of 36.4 % and 89.9 %, respectively. The optimum conditions of the Schiff base synthesis were as following： temperature 30℃. time 30 min, 2-（3 formyl-4-hydroxyphenyl）-2-（4-hydroxyphenyl）propane：benzidine=3：1. 2-（3-formyl-4-hydroxyphenyl）-2-（4-hydroxyphenyl） propane and the benzidine schiff base were characterized by IR, 1HNMR spectra.