治伤软膏外敷治疗大鼠急性软组织损伤的实验研究

Experimental Research for External Use of Wound Ointment in the Treatment of Acute Soft Tissue Injure in Rat Models

目的:观察治伤软膏局部外敷对急性软组织损伤模型大鼠的治疗效果,并探讨其作用机理。方法:将30只SD大鼠制成动物模型,随机分为治疗组(A)、对照组(B),A组用治伤软膏外敷治疗,B组空白对照。用药第3、5、10d作大体观察、光镜下组织观察、血液流变检测。结果:两组大体观察各时相评分比较差异无统计学意义(P>0.05);第5d A组组织病理革兰氏染色评分优于B组(P<0.01);血液流变学检测显示A组用药后各时相全血粘度(低、中切)、红细胞压积、全血还原粘度(低切)都明显低于B组(P<0.01)。结论:治伤软膏外用治疗急性血瘀证模型大鼠,能明显降低血液粘度、改善其血液流变性,促进损伤组织的修复。

Objective：To observe the therapeutic efficacy of external use of wound ointment （WO） in treating acute soft tissue injury （ASTI） in rat models. Methods：ASTI models were established in 30 SD rats, which were randomly divided into treatment group （A） and control group （B）. Group A were treated with wound ointment for 3, 5 and 10 days. General condition, hemorrheology and pathological tissue section were observed. Results：There was no difference in general condition of both groups at each time point （P〉0.05）. At Day 5 the grade of group A was better than that of group B in pathological tissue section. Hemorrheological analysis indicated that blood viscosity, HCT and whole blood reduced viscosity in treatment group were significantly lower than those in control group at each time point （P〈0.01）. Conclusion： WO could efficiently decrease the blood viscosity and change the hemorrheology to promote damaged tissue repair while in treating ASTI rats.