摘要
目的系统评价肿瘤相关抗原CA72-4对胃癌的诊断效能。方法检索2002年1月至2008年12月万方中文科技期刊数据库和维普中文科技期刊数据库中关于CA72-4对胃癌的临床诊断价值的中文文献,对纳入文献进行质量评价及异质性检验,用统计分析软件计算综合受试者工作特征(SROC)曲线方程。结果共检索到2002年1月至2008年12月公开发表的关于CA72-4在胃癌临床诊断中的应用文献59篇,根据纳入和排除标准,经筛选后的7篇文献与本实验室研究结果共计7组数据进行Meta分析,样本总量为1748份。合并后的敏感度、特异度及优势比值分别为55.4%、91.5%和65.69。SROC曲线下面积为0.8746。结论CA72-4对胃癌具有中等水平的诊断价值。
Objective To assess the effect of tumor marker CA72-4 in the diagnosis of gastric cancer. Methods Relevant articles published in English and Chinese from January 2002 to December 2008 were searched for the data bases in Weipu and Wanfang full text. After the elicited articles were evaluated, the pooled sensitivity, specificity and odds rate were calculated by summary receiver operating charaeteristic （SROC） curve. Results From 59 related literatures index in the data bases, 7 articles involved in 1 748 samples were selected out to enter this meta-analysis,with the pooled sensitivity,specificity and odds tale being 55.4% , 91.5% and 65. 69 respectively. The area under the SROC curve was 0. 874 6. Conclusion CA72-4 has a moderate value in the diagnosis of gastric cancer .
出处
《检验医学与临床》
CAS
2009年第16期1322-1323,1325,共3页
Laboratory Medicine and Clinic
关键词
抗原
肿瘤相关
碳水化合物
META分析
胃肿瘤
评价研究
antigens, tumor-associated, carbohydrate
meta-analysis
stomach neoplasms
evaluation studies
